Environmentally Friendly Alkylphosphonate Herbicides, Softcover reprint of the original 1st ed. 2014

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Language: Anglais

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Environmentally Friendly Alkylphosphonate Herbicides
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Environmentally Friendly Alkylphosphonate Herbicides
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455 p. · 15.5x23.5 cm · Hardback

This book presents essential research on a class of environmentally friendly alkylphosphonate herbicides. This class of herbicides acted as a competitive inhibitor of the pyruvate dehydrogenase complex (PDHc) to control weeds. The bioreasoning and systematic approach, from basic research to field tests of candidate compounds, are introduced. The basic research covers the molecular design, chemical synthesis, biological activities evaluation, structure-activity relationship analysis and structural optimization. Subsequently, the book reviews the biochemistry of PDHc inhibitors, the selectivity between mammals and plants, and the mechanism of herbicidal activity of novel alkylphosphonates as selective PDHc inhibitors. Field trials for selected alkylphosphonate candidates as herbicides are also included. This book provides a sound basis for the rational design and development of novel herbicides as effective PDHc inhibitors with good enzyme-selective inhibition of plant PDHc between mammals and plants. These studies take full advantages of the low toxicity and low residual impact of selective PHDc inhibitors to design an effective and environmentally friendly herbicide. This book is based on twenty years of research on alkylphosphonates and phosphorus-containing PDHc inhibitors, and demonstrates how to develop these PDHc inhibitors as an effective and “green” herbicide candidate.

Overview.- Alkylphosphonates.- Salts of Alkylphosphonates.- Alkylphosphinates.- Cyclic Phosphonates and Caged Bicyclic Phosphates.- Optically Active Alkylphosphonates.- Biochemistry and Mechanism of Alkylphosphonates as PDHc Inhibitors.- Evaluation and Application of Clacyfos and HWS.- General Methology.

Presents the design and development of pyruvate dehydrogenase complex (PDHc) inhibitors as effective novel herbicides

Introduces the systematical approach to develop novel alkylphosphonates with desirable biological activities

Covers the results of research and development of environmentally friendly alkylphosphonate herbicides