Chemistry for pharmacy students: General organic & natural products chemistry
General, Organic and Natural Product Chemistry

Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural product chemistry (in relation to drug molecules) suitable for the undergraduate curricula in Pharmacy (Bpharm/MPharm). Clearly structured to enhance student understanding the book is divided into 6 clear sections: An overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications, The concepts of atomic structure and bonding, The fundamentals of stereochemistry and their importance in pharmacy- in relation to drug action and toxicity, Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance, Organic reactions and their applications to drug discovery and development with the final chapter discussing natural product chemistry. Clearly structured with a focus on the properties and actions of drug molecules. Entire chapter devoted to natural product chemistry. Includes learning objectives at the beginning of each chapter Includes supplementary material such as PowerPoint's and case studies.

Preface. 1. Introduction. 1.1 Role of chemistry in modern life. 1.2 Physical properties of drug molecules. 2. Atomic structure and bonding. 2.1 Atoms, elements and compounds. 2.2 Atomic structure: orbitals and electronic configurations. 2.3 Chemical bonding theories: formation of chemical bonds. 2.4 Electronegativity and chemical bonding. 2.5 Bond polarity and intermolecular forces. 2.6 Significance of chemical bonding in drug-receptor interactions. 3. Stereochemistry. 3.1 Stereochemistry: definition. 3.2 Isomerism. 3.3 Significance of stereoisomerism in determining drug action and toxicity. 3.4 Synthesis of chiral molecules. 3.5 Separation of stereoisomers: resolution of racemic mixtures. 3.6 Compounds with stereocentres other than carbon. 3.7 Chiral compounds that do not have a tetrahedral atom with four different groups. 4. Organic functional groups. 4.1 Organic functional groups: definition and structural features. 4.2 Hydrocarbons. 4.3 Alkanes, cycloalkanes and their derivatives. 4.4 Alkenes and their derivatives. 4.5 Alkynes and their derivatives. 4.6 Aromatic compounds and their derivatives. 4.7 Heterocyclic compounds and their derivatives. 4.8 Nucleic acids. 4.9 Amino acids and peptides. 4.10 Importance of functional groups in determining drug actions and toxicity. 4.11 Importance of functional groups in determining stability of drugs. 5. Organic reactions. 5.1 Types of organic reaction. 5.2 Radical reactions: free radical chain reactions. 5.3 Addition reactions. 5.4 Elimination reactions: 1,2-elimination or -elimination. 5.5 Substitution reactions. 5.6 Hydrolysis. 5.7 Oxidation?reduction reactions. 5.8 Pericyclic reactions. 6. Natural product chemistry. 6.1 Introduction to natural products drug discovery process. 6.2 Alkaloids. 6.3 Carbohydrates. 6.4 Glycosides. 6.5 Terpenoids. 6.6 Steroids. 6.7 Phenolics.

Dr Satyajit Sarke BPharm (Hons) MPharm PhD FHEA. Reader in Pharmacy; Course Director, BSc (Hons) Pharmacology; Chair, MPharm Course Planning Committee; Chair, MSc Pharmaceutical Sciences Course Planning Committee; Owner and moderator: www.jiscmail.ac.uk/natprodis and www.jiscmail.ac.uk/pharmed; School of Biomedical Sciences, University of Ulster at Coleraine, Northern Ireland, UK.

Dr Lutfun Nahar. School of Biomedical Sciences, University of Ulster at Coleraine, Northern Ireland, UK.