Chiral separations (2nd Ed., 2nd ed. 2013)
Methods and protocols

Methods in molecular biology, Vol. 970 Series, Vol. 970

Coordinator: Scriba Gerhard K. E.

Language: Anglais

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Chiral Separations (2nd Ed.)
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Chiral separations (2nd Ed.)
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There is a demand for analytical methods that are able to discriminate between enantiomers in order to analyze the enantiomeric purity of compounds from natural or chemical sources not only in pharmaceutical sciences but in any field on bioactive compounds including chemistry, biology, biochemistry, forensic, and environmental sciences and many others. The second edition of Chiral Separations: Methods and Protocols, expands upon the previous edition with current methodology, providing an overview and especially practically oriented applications of the most important analytical techniques in chiral separation sciences. New chapters on analytical separation sciences by chromatographic and electrophoretic techniques have been added as has simulated moving bed chromatography as a preparative method. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Chiral Separations: Methods and Protocols, Second Edition is helpful for analytical chemists working on stereochemical problems in fields or pharmacy, chemistry, biochemistry, food chemistry, molecular biology, forensics, environmental sciences or cosmetics in academia, government or industry.

1. Chiral Recognition in Separation Science – An Overview

2. Enantioseparations by Thin-Layer Chromatography

3. Gas Chromatographic Enantioseparation of Unfunctionalized Chiral Hydrocarbons - An Overview

4. HPLC-Enantioseparation on Cyclodextrin-based Chiral Stationary Phases

5. Enantioseparations by High Performance Liquid Chromatography Using Polysaccharide-Based Chiral Stationary Phases – An Overview

6. Common Screening Approaches for Efficient Analytical Method Development in LC and SFC on Columns Packed with Immobilized Polysaccharide-derived Chiral Stationary Phases

7. Chiral Separations by HPLC on Immobilized Polysaccharide Chiral Stationary Phases

8. Enantioseparations by High-Performance Liquid Chromatography Using Macrocyclic Glycopeptide-Based Chiral Stationary Phases – An Overview

9. Enantioseparations of Primary Amino Compounds by High Performance Liquid Chromatography Using Chiral Crown Ether-Based Chiral Stationary Phase

10. Screening of Pirkle-type Chiral Stationary Phases for HPLC Enantioseparations

11. Enantioseparations by High Performance Liquid Chromatography Based on Chiral Ligand Exchange

12. Enantioseparations by High Performance Liquid Chromatography Using Molecularly Imprinted Polymers

13. Chiral Mobile Phase Additives in HPLC Enantioseparations

14. Chiral Benzofurazan-Derived Derivatization Reagents for Indirect Enantioseparations by HPLC

15. Separation of Racemic 1-(9-anthryl)-2,2,2-trifluoroethanol by Sub-/supercritical Fluid Chromatography

16. Chiral Separations by Simulated Moving Bed Method Using Polysaccharide-Based Chiral Stationary Phases

17. Enantioseparations by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors

18. Application of Dual Cyclodextrin-Systems in Capillary Electrophoresis Enantioseparations

19. Enantioseparations in Nonaqueous Capillary Electrophoresis Using Charged Cyclodextrins

20. Use of Macrocyclic Antibiotics as the Chiral Selectors in Capillary Electrophoresis

21. Application of Polymeric Surfactants in Chiral Micellar Electrokinetic Chromatography (CMEKC) and CMEKC Coupled to Mass Spectrometry

22. Cyclodextrin-modified Micellar Electrokinetic Chromatography for Enantioseparations

23. Cyclodextrin-mediated Enantioseparation in Microemulsion Electrokinetic Chromatography

24. Chiral Separations by Capillary Electrophoresis Using Proteins as Chiral Selectors

25. Enantioseparation by Chiral Ligand-Exchange Capillary Electrophoresis

26. Experimental Design Methodologies in the Optimization of Chiral CE or CEC Separations – An Overview

27. Chiral Capillary Electrophoresis-Mass Spectrometry

28. Application of Chiral Ligand-Exchange Stationary Phases in Capillary Electrochromatography

29. Polysaccharide-Derived Chiral Stationary Phases in Capillary Electrochromatography Enantioseparations

30. Open Tubular Molecular Imprinted Phases in Chiral Capillary Electrochromatography

Focuses on analytical seperation sciences by chromatographic and electrophoretic techniques

Provides step-by-step detail essential for reproducible results

Contains key notes and implementation advice from the experts