Discovery and Development of Antidiabetic Agents from Natural Products
Natural Product Drug Discovery
Natural Product Drug Discovery Series

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Language: English

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332 p. · 15x22.8 cm · Paperback

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic.

Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications.

Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics.

Chapter 1. Andrographolide: A Molecule of Antidiabetic Promise

Chapter 2. Computer-Aided Discovery of Glycogen Phosphorylase Inhibitors Exploiting Natural Products

Chapter 3. Identification and Extraction of Antidiabetic Antioxidants from Natural Sources

Chapter 4. Glucose Transporter 4 Translocation Activators From Nature

Chapter 5. Carbohydrate-Based Antidiabetic Agents From Nature

Chapter 6. Recent Developments on the Antidiabetic Sesquiterpene Lactones and Their Semisynthetic Analogues

Chapter 7. Prediction of Prediabetes and Its Prevention by Functional Food Compounds

Chapter 8. Immunomodulators in Prophylaxis and Therapy of Type-1 Diabetes

Chapter 9. α-Glucosidase Enzyme Inhibitors From Natural Products

Chapter 10. Treasures of Indigenous Indian Herbal Antidiabetics: An Overview

Primarily medicinal chemists and researchers into antidiabetic drug design and drug leads from natural products, with a secondary audience of pharmacologists, biochemist and medical professionals involved in pre-clinical testing, clinical trials and application of antidiabetic drugs. Also of interest to post-grad and academic researchers in these fields

Born on April 14, 1969 in Barala, a village in the district of Murshidabad (West Bengal, India), Goutam Brahmachari had his early education in his native place. He received his high school degree in scientific studies in 1986 at Barala R. D. Sen High School under the West Bengal Council of Higher Secondary Education (WBCHSE). Then he moved to Visva-Bharati (a Central University founded by Rabindranath Tagore at Santiniketan, West Bengal, India) to study chemistry at the undergraduate level. After graduating from this university in 1990, he completed his master’s in 1992 with a specialization in organic chemistry. After that, receiving his Ph.D. in 1997 in chemistry from the same university, he joined his alma mater the very next year and currently holds the position of a full professor of chemistry since 2011. The research interests of Prof. Brahmachari’s group include natural products chemistry, synthetic organic chemistry, green chemistry, and the medicinal chemistry of natural and natural product-inspired synthetic molecules. With about 23 years of experience in teaching and research, he has produced 235 scientific publications, including original research papers, review articles, books, and invited book chapters in the field of natural products and green chemistry. He has already authored/edited 26 books published by internationally reputed major publishing houses, namely, Elsevier Science (The Netherlands), Academic Press (Oxford), Wiley-VCH (Germany), Alpha Science International (Oxford), De Gruyter (Germany), World Scientific (Singapore), CRC Press (Taylor & Francis Group, USA), Royal Society of Chemistry (Cambridge), etc. Prof. Brahmachari serves as a life member for the Indian Association for the Cultivation of Science (IACS), Indian Science Congress Association (ISCA), Kolkata, and Chemical Research Society of India (CRSI), Bangalore. He has also been serving as an associate editor for Current Green Chemistry.

Prof. Brahmachari serves as the founde
  • Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery
  • Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues
  • Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab