Description
New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations, 1st ed. 2017
Springer Theses Series
Author: Chen Xiangyu
Language: EnglishSubject for New Strategies for N-Heterocyclic Carbenes Catalyzed...:
Publication date: 12-2016
Support: Print on demand
Publication date: 07-2018
Support: Print on demand
Description
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This thesis focuses on NHC-catalyzed annulation of nitroalkenes, enals and ?,?-unsaturated carboxylic acids. (1) NHCs were found to be efficient catalysts for the [4+2] annulation of ?-substituted nitroalkenes. The scope of Rauhut?Currier reaction was successfully extended to the most challenging ?-substituted alkenes by this method; (2) Enals were successfully used for [4+2] annulations with azodicarboxylates catalyzed by NHC via ?-addition. Highly enantiopure tetrahydropyridazinones and ?-amino acid derivatives could be easily prepared by subsequent transformations of the resulting dihydropyridazinones. (4) The readily available ?,?-unsaturated carboxylic acids were first successfully employed to generate the ?,?-unsaturated acyl azolium intermediates by using NHC for the enantioselective [3+2] and [3+3] annulations.
Introduction.- NHC-catalyzed Annulations of Nitroalkenes.- NHC-catalyzed Enantioselective Annulations of Enals.- NHC-catalyzed Enantioselective Annulations of α,β-unsaturated Carboxylic Acids.- Experimental Part.- Research Summary.
Nominated by Chinese Academy of Sciences as an outstanding PhD thesis
Provides new methodologies of N-heterocyclic carbene catalysis
Describes in detail the annulation reactions of nitroalkenes, enals and a,ß-unsaturated carboxylic acids
Includes supplementary material: sn.pub/extras