Strategies and Tactics in Organic Synthesis
Strategies and Tactics in Organic Synthesis Series

Strategies and Tactics in Organic Synthesis, Volume 13, provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project present the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project.

Readers will be educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs and building molecules with atom and step economies that provide functional solutions to create a better world.

1. The chemistry of Lobelia alkaloids: an inexhaustible source for molecular diversity 2. Cross-Coupling Free Synthesis of Strained and Congested Biaryl Macrocycles 3. Application of metallacycle-mediated annulatiive cross-coupling chemistry to neurotrophic seco-prezizaane natural products 4. Bio-inspired adventures in the total synthesis of cytochalasans and biosynthetically related natural products 5. Total Synthesis of Ipomoeassin F and Its Analogues for Biomedical Research 6. Total synthesis of guaianoids through a strategy powered by organocatalytic [4+3] cycloaddition reactions 7. The Development of Strategies and Tactics Toward the Pseudopterosin Natural Products: Ileabethoxazole As a Platform for Target-Inspired Discovery 8. Total synthesis of the lindenane-associated terpenoids 9. Total Synthesis of Dehaloperophoramidine: Evolution of a Synthesis

Organic chemists; academic libraries; chemical and pharmaceutical companies

In 1980, he began graduate studies in chemistry at the University of Illinois-Champaign/Urbana where he was awarded a University Teaching Fellowship. He worked with Professor Scott E. Denmark on the invention of the carbanion-accelerated Claisen rearrangement. In his second year of study, he was awarded an Eastman Kodak Research Fellowship.

Upon graduation in 1985, he was awarded an NIH postdoctoral fellowship which he used to study with Professor Paul A. Wender at Stanford University, where he worked on the synthesis of the neocarzinostatin chromophore.

In 1986, Prof. Harmata began his independent career at the University of Missouri-Columbia. He became an Associate Professor in 1992 and a full professor in 1998. In 2000, he was named the Norman Rabjohn Distinguished Professor of Chemistry in recognition of his achievements in research and teaching. In 1998, he received a research fellowship from the Alexander von Humboldt Foundation and stayed for a year at the University of Göttingen where he was affiliated with the groups of Professors Reinhard Brückner and Lutz. F. Tietze. In 2000, he served as chair of the Gordon conference on Organic Reactions and Processes. In 2010, he was named the first Justus Liebig Professor of Chemistry at the Justus Liebig Üniversität in Giessen, Germany. In 2011, he was a JSPS fellow. He has been a visiting professor in Giessen and Strasbourg and has delivered over 180 invited lectures in the United States and Europe. He is a member of the American Chemical Society, Gesellschaft Deutscher Chemiker, International Society of Heterocyclic Chemistry, and the Alexander von Humboldt Association of America.

• Presents state-of-the-art developments in organic synthesis
• Provides insight and offers new perspective to problem-solving
• Written by leading experts in the field
• Uses firsthand narrative accounts to vividly illustrate the challenges and joys involved in advancing the science of organic synthesis