Supercritical Fluid Chromatography
Handbooks in Separation Science Series

Coordinator: Poole Colin F.

Language: English
Cover of the book Supercritical Fluid Chromatography

Subject for Supercritical Fluid Chromatography

Keywords

2D interface; 2D-SFC; Accuracy profile; Achiral purification; Adsorption isotherm; Alkaloids; Applications; Assay; Biological matrices; Bubble point; Carbon dioxide; Carotenoids; Chiral resolution; Chiral selectors; Chiral separation; Chiral stationary phases; Column back pressure; Column classification; Column coupling; Column dimension; Column technology; Compressibility; Core-shell particles; Critical locus; Critical point; Critical temperature; Density; Detection sensitivity; Dew point; Diastereomers; Dietary supplements; Diffusion; Drug development; Drug discovery; Efficiency; Enantiomers; Enantioselective chromatography; Enantioseparation; Equilibrium isotherm; Food analysis; Frontal analysis; GC×GC; Group-type separation; High-throughput purification; History; Hyphenated systems; Hyphenation; ICH; Impurity profiling; Instrumentation; Interfacing approach; Inverse method; Kinetic plots; Lipid analysis; Lipidomics; Lubricant additives; Mass spectrometry; Matrix effects; Method development; Method validation; Model-based method; Modeling; Modifier; Modifiers; Multidimensional chromatography; Natural products; Oils; Packed column; Packed columns; Parallel segmented flow SFC; Pesticides; Petroleum compounds; Pharmaceutical application; Phase behavior; Phase diagram; Physicochemical measurements; Plate height; Porous shell particle; Preparative separation; Preparative supercritical fluid chromatography; Pressure; Primary additives; Pump drive; Resolution; Retention factor; Retention theory; Robustness; Rule-based method; SFC; SFC-MS; Secondary additives; Selectivity; Separation; Simulated distillation; Solubility; Stability; Stationary phases; Steroids; Supercritical fluid chromatography; Supercritical fluid chromatography (SFC)

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Supercritical fluid chromatography (SFC) is a rapidly developing laboratory technique for the separation and identification of compounds in mixtures. Significant improvements in instrumentation have rekindled interest in SFC in recent years and enhanced its standing in the scientific community. Many scientists are familiar with column liquid chromatography and its strengths and weaknesses, but the possibilities brought to the table by SFC are less well-known and are underappreciated.

Supercritical Fluid Chromatography is a thorough and encompassing reference that defines the concept of contemporary practice in SFC and how it should be implemented in laboratory science. Given the changes that have taken place in SFC, this book presents contemporary aspects and applications of the technique and introduces SFC as a natural solution in the larger field of separation science. The focus on state-of-the-art instrumental SFC distinguishes this work as the go-to reference work for those interested in implementing the technique at an advanced level.

1. Milestones in Supercritical Fluid Chromatography: A Historical View of the Modernization and Development of Supercritical Fluid Chromatography 2. Theory of Supercritical Fluid Chromatography 3. Practical Approaches to Column Selection for Supercritical Fluid Chromatography 4. Column Characterization 5. Method Development in Supercritical Fluid Chromatography 6. Application of Multiple Column Supercritical Fluid Chromatography 7. Evolution of Instrumentation for Analytical Scale Supercritical Fluid Chromatography 8. Hyphenated Detectors: Mass Spectrometry 9. Theories for Preparative SFC 10. Practical Aspects and Applications of Preparative Supercritical Fluid Chromatography 11. Validation of Supercritical Fluid Chromatography Methods 12. Separation of Stereoisomers 13. Supercritical Fluid Chromatography of Petroleum Products 14. Separation of Lipids 15. Separation of Natural Products 16. Pharmaceutical Applications 17. Applications to Food Analysis 18. Physicochemical Property Measurements Using SFC Instrumentation

Analytical chemists, pharmaceutical scientists, medicinal chemists, in addition to instructors and students taking related coursework. Secondary audience includes junior scientists entering or working in the field of supercritical fluid chromatography to consolidate their knowledge and improve their skills.

Prof. Colin F. Poole was born and educated in the United Kingdom receiving a B.Sc. in Chemistry from the University of Leeds (1971) followed by graduate studies at the University of Bristol, MSc. in analytical chemistry (1972), and Ph.D. with Prof. E. D. Morgan at the University of Keele (1975) on the analysis of insect moulting hormones. Since 1980 he has been at the Department of Chemistry, Wayne State University, Detroit, Michigan, USA , except for 1995-1996, spent as the Governors’ Lecturer and Professor of Analytical Chemistry at Imperial College of Science, Technology & Medicine, London, in the United Kingdom. He is a former Science Advisor to the US Food and Drug Administration, a position he occupied for 25 years. Professor Poole has broad interests in the separation and detection of small molecules in biological, environmental, and food samples using a range of sample preparation, chromatographic and data analysis tools. He is the co-author of over 400 papers, 20 books, an editor of Journal of Chromatography A and a member of the editorial boards of 5 other analytical chemistry journals.
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  • Edited and authored by world-leading chromatography experts
  • Provides comprehensive coverage of SFC in a single source
  • Extensive referencing facilitates identification of key research developments
  • More than 200 figures and tables aid in the retention of key concepts