Handbook of Nutrition, Diet, and Epigenetics, 1st ed. 2019

This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting.  Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Nervous system.-  Development and ageing.-  Cancers.-  Caloric and dietary restriction.- Detailed processes in epigenetics of diet and nutrition.-Modifications of DNA via methylation.- Modifications of histones.- Modifications of non-coding  RNAs.- DNA repair.- Modulating epigenetics with diet and nutrition.- General treatments and strategies.- Vitamins.- Minerals.- Specific foods and nutrients.- Nutritional toxicology.-  Practical techniques.

Victor R. Preedy (B.Sc., Ph.D., D.Sc., FRSB, FRSPH, FRCPath, FRSC) is a senior member of King’s College London, where he is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy graduated in 1974 with an Honors Degree in Biology and Physiology with Pharmacology. He gained his University of London Ph.D. in

of the Royal Society of Chemistry. In his career, Professor Preedy has carried out research at the National Heart Hospital (part of Imperial College London), the School of Pharmacy (now part of University College London), and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, the USA, and Germany. He is a leading expert in the science of health and has a long-standing interest in food and nutrition for over 30 years,

especially related to tissue pathology and cellular and molecular biology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which include peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews, and numerous books and volumes.

Vinood B. Patel (B.Sc., Ph.D., FRSC) is a Reader in Clinical Biochemistry at the University of Westminster and honorary Fellow at King’s College London. Dr. Patel graduated from 1992 the Un

Addresses emerging and established fields of epigenetics in connection with diet and nutrition

Expands the knowledge base and maps out key areas for research

Contributors are authors of international and national standing

Each chapter contains an abstract, summary, key facts, and glossary

Includes supplementary material: sn.pub/extras