L-Arginine in Clinical Nutrition, 1st ed. 2017
Nutrition and Health Series

This text presents the application of current nutritional knowledge by physicians and dietitians and incorporates emerging fields of science and important discoveries.  It contains seven major sections. Section 1: Basic Processes at the Cellular Levels, Section 2: Arginine Metabolism and Functions, Section 3: Arginine Status in Cells Related to Organ Damage and Disease, Section 4: Arginine Status and Use in Healthy Individuals, Section 5: Arginine and Diseases of the Gastrointestinal Tract, Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases and Section 7: Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease.

Written by authors of international and national standing, leaders in the field and trendsetters, Arginine in Clinical Nutrition is essential reading for nutritionists and dietitians, public health scientists, doctors, epidemiologists, health care professionals of various disciplines, policy makers and marketing and economic strategists. 

Section 1: Basic Processes at the Cellular Levels

Chapter 1 - Arginine uptake by cells - Geoffrey P. Candy and Marietha J. Nel

Chapter 2 - L-arginine and the expression of HSP70 and p-53 proteins - Agnieszka Pedrycz and Victor R. Preedy

Chapter 3 - AMP-activated protein kinase and L-arginine - Srinidi Mohan

Chapter 4 - Amidine-based compounds affecting arginine metabolism - Cristina Maccallini, Marialuigia Fantacuzzi and Rosa Amoroso

Chapter 5 - Oxy- and sulfoanalogues of L-arginine - Tatyana Dzimbova and Tamara Pajpanova

Chapter 6 - Regulation of expression and activity of L-arginine transporters by nutrients and hormones: A focus in transcriptional mechanisms regulated by glucose and insulin - Marcelo González

Chapter 7 - Arginine, pancreatic beta cell function and diabetes: mechanisms of stimulated insulin release and pathways of metabolism - Philip Newsholme, Kevin N. Keane, Mina Elahy and Vinicius Fernandes Cruzat

Chapter 8 - Erythrocytes by-products of arginine catabolism - Martha Lucinda Contreras-Zentella and Rolando Hernández-Muñoz                                                                               

Section 2: Arginine Metabolism and Functions

Chapter 9 - Arginine synthesis from enteral proline - Christopher Tomlinson, Ronald O. Ball and Paul B. Pencharz

Chapter 10 - Arginine and macrophages: role in classical and alternative activation

 - Jorge Lloberas, Manuel Modolell and Antonio Celada

Chapter 12 - Arginine metabolism impairment during sepsis and diseases: causes and consequences - Christophe Moinard, Charlotte Breuillard and Christine Charrueau

Chapter 13 - Use of arginine with Growth Hormone Releasing Hormone (GHRH) and the endocrine response - Giulia Brigante and Vincenzo Rochira

Chapter 14 - Serum arginase in healthy subjects and nitric oxide - Keiki Ogino and Kei Takemoto                                     

Section 3: Arginine Status in Cells Related to Organ Damage and Disease

Chapter 15 - Protein Arginine Methylation of RNA-binding Proteins and Their Impact on Human Diseases - Michael C. Yu and Christopher A. Jackson

Chapter 16 - DNA-arginine adducts and implications in disease - Haseeb Ahsan

Chapter 17 - Homoarginine and L-arginine: Glycine amidinotransferase in stroke - Chi-un Choe, Edzard Schwedhelm and Dorothee Atzler

Chapter 18 - The L-arginine/asymmetric dimethylarginine (ADMA) ratio in health and disease: an overview - Murat Celik and Hilmi Umut Unal

Chapter 19 - Arginine and its transporters in colorectal cancer - Bingguan Chen, Weimin Wang, Kang Ding, Junchen Wang, Peng Gao, Guowang Xu and Hai Hu

Chapter 20 - Arginine Uptake and Its Role in the Survival of Breast Cancer Cells - Catherine K. L. Too and Salma A. Abdelmagid          

Section 4: Arginine Status and Use in Healthy Individuals                                                                                                 

Chapter 21 - Arginine production during pregnancy - Farook Jahoor, Jean W. Hsu, Pratibha Dwarkanath, Minerva M. Thame and Anura V. Kurpad

Chapter 22 - L-arginine in the uterus and placenta and during gestation in mammals - Jonathan M. Greene and Peter L. Ryan            

Chapter 23 - Oral L-arginine supplementation in young males: endocrinology, metabolic, and physiological responses at rest and during exercise - Scott C. Forbes

Chapter 24 - Metabolic precursors of L-Arginine supplementation in sport: a focus on L-Citrulline and L-Ornithine - Antoni Pons, Raúl Bescós, Antoni Sureda and Josep A. Tur

Section 5: Arginine and Diseases of the Gastrointestinal Tract 

Chapter 25 - Arginine and its use in ameliorating Cryptosporidium parvum infection in undernourished children - Reinaldo Barreto Oriá, Orleâncio Gomes Ripardo de Azevedo, Theídes Batista Carneiro, Aldo Ângelo Lima and Richard L. Guerrant

Chapter 26 - Arginine and Inflammatory Bowel Disease (IBD) - Wenkai Ren, Gang Liu, Shuai Chen and Yulong Yin

Chapter 27 - Dietary L-arginine and intestinal recovery - Igor Sukhotnik

Chapter 28 - Enteral and parenteral arginine supplementation in intestinal ischemia and reperfusion injury - Chun-Hong Lai and Hui-Chen Lo

Chapter 29 - Mucosal Protection by Arginine in the Upper Gastrointestinal Tract - Koji Takeuchi               

Chapter 30 - Enteral L-arginine and necrotizing enterocolitis - Sophia Zachaki, Stavroula Gavrili, Elena Polycarpou and Vasiliki I. Hatzi

Section 6: Therapeutic uses of Arginine: Diabetes, Obesity and Cardiovascular Diseases

Chapter 31 - L-arginine usage in Type I diabetes: From the autoimmune event to human dietary supplementation - Mauricio Krause, Ana Paula Trussardi Fayhand Alvaro Reischak-Oliveira

Chapter 32 - Oral l-arginine supplementation and glucose metabolism and vascular function - Lucilla D. Monti, Elena Galluccio, Barbara Fontana and Piermarco Piatti

Chapter 33 - Arginine enriched apples and diabetic control - Andrea Escudero, Jorge Moreno, Jesenia Acurio and Carlos Escudero

Chapter 34 - Beneficial impact of cod protein, arginine and other amino acids on insulin sensitivity - Veronique Ouellet, S. John Weisnagel, Denis R. Joanisse, Charles Lavigne, Junio Dort, André Marette and Hélène Jacques 

Chapter 35 - Obese subjects and supplemental L-arginine - Pawel Bogdanski, Joanna Suliburska Matylda Kręgielska-Narożna, Anna Jablecka and Jarosław Walkowiak

Chapter 36 - Mitochondrial cardiomyopathy and usage of L-arginine - Kenichiro Arakawa, Masamichi Ikawa, Hiroshi Tada, Hidehiko Okazawa and Makoto Yoneda

Chapter 37 - Arginine Measurement and Concentrations in Hypertension and other Cardiovascular Disease - Cameron Naidoo and Geoffrey P. Candy

Chapter 38 - L-Arginine and cardiovascular disease - Norbert J. Tripolt and Harald Sourij

Chapter 39 - Arginine therapy in sickle cell disease - Claudia R. Morris

Section 7:Therapeutic Uses of Arginine: Cancer, Wound Healing and Infectious Disease

Chapter 40 - Role of arginine in surgical patients with head and neck cancer - Daniel de Luis, Rocio Aller and Pablo Casas-Rodera

Chapter 41 - Arginine-Incorporated Albumin Mesospheres: A Drug Delivery System for Cancer Therapy - Hung-Yen Lee, Kamal A. Mohammed and Nasreen Najmunnisa

Chapter 42 - Use of L-arginine and glycine supplementation to reduce radiotherapy damage -Cristina Fajardo Diestel, Nara Limeira Horst, Alessandra da Rocha Pinheiro Mulder and Ruy Garcia Marques

Chapter 43 - Arginine in Cancer Therapy - Lynn G. Feun, Medhi Wangpaichitr, Chunjing Wu, Ying-Ying Li, Min You, Macus Tien Kuo, Niramol Savaraj

Chapter 44 - Mechanisms of Arginine-Auxotrophic Response and Their Cancer Therapeutic Implications - Wen-Bin Tsai, Yan Long, Niramol Savaraj, Lynn G. Feun and Macus Tien Kuo

Chapter 45 - The role of arginine in wound healing - Alan N. Gould and Geoffrey P. Candy

Chapter 46 - L-arginine and bacterial translocation: implications for health - Mirelle Lomar Viana, Simone de Vasconcelos Generoso, Rosana das Graças Carvalho dos Santos, Valbert Nascimento Cardoso and Maria Isabel Toulson Davisson Correia

Chapter 47 - L-arginine in Pulmonary Tuberculosis - Anna P. Ralph

Chapter 48 - Arginine in Health and Disease: Recommended Resources and Further Reading - Rajkumar Rajendram, Vinood B. Patel and Victor R. Preedy

Written by an international group of expert authors

Presents emerging fields of science and important discoveries

Each chapter contains key points and keywords for ready reference