Description
Applied Surrogate Endpoint Evaluation Methods with SAS and R
Chapman & Hall/CRC Biostatistics Series
Authors: Alonso Ariel, Bigirumurame Theophile, Burzykowski Tomasz, Buyse Marc, Molenberghs Geert, Muchene Leacky, Perualila Nolen Joy, Shkedy Ziv, Van der Elst Wim
Language: EnglishSubject for Applied Surrogate Endpoint Evaluation Methods with SAS and R:
Keywords
Trial Level Surrogacy; True Endpoint; true; Individual Level Surrogacy; trial; Surrogate Endpoint; level; Trial Specific Treatment Effects; surrogacy; Information Theoretic Approach; individual; Marginal Models; hasselt; Joint Model; university; ARMD Trial; age-related; Progressive Disease; macular; Plackett Copula; degeneration; Variance Covariance Matrix; ARMD; Binary Endpoints; Univariate Linear Regression Model; Advanced Colorectal Cancer; Estimated Treatment Effects; SAS Macro; Mixed Effects Model; Progression Free Survival; Expected Treatment Effect; Asymptotic Confidence Interval; PANSS; Class Trial; Mutual Information
57.55 €
In Print (Delivery period: 14 days).
Add to cart the book of Alonso Ariel, Bigirumurame Theophile, Burzykowski Tomasz, Buyse Marc, Molenberghs Geert, Muchene Leacky, Perualila Nolen Joy, Shkedy Ziv, Van der Elst WimPublication date: 12-2020
· 15.6x23.4 cm · Paperback
89.57 €
In Print (Delivery period: 15 days).
Add to cart the book of Alonso Ariel, Bigirumurame Theophile, Burzykowski Tomasz, Buyse Marc, Molenberghs Geert, Muchene Leacky, Perualila Nolen Joy, Shkedy Ziv, Van der Elst WimPublication date: 12-2016
374 p. · 15.6x23.4 cm · Hardback
Description
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An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment?s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.
Introductory Material. Introduction. Notation and Example Datasets. The History of Surrogate Endpoint Validation. Contemporary Surrogate Endpoint Evaluation Methods. Multiple-Trial Surrogate Endpoint Evaluation Methods. Two Continuous Outcomes. Two Survival Endpoints. Two Categorical Endpoints. A Categorical and a Continuous Endpoint. A Survival and a Continuous Endpoint. A Survival and a Categorical Endpoint. Two Longitudinal Endpoints. A Longitudinal and a Survival Endpoint. Additional Considerations and Further Topics. Software Details. An Alternative Surrogate Endpoint Evaluation Framework: Causal-Inference. Surrogate Endpoint Evaluation Methods in Small Samples. Construction and Evaluation of Genetic Biomarkers in Early Drug Development Experiments. Additional Considerations.
Ariel Alonso, Theophile Bigirumurame, Tomasz Burzykowski, Marc Buyse, Geert Molenberghs, Leacky Muchene, Nolen Joy Perualila, Ziv Shkedy, Wim Van der Elst