Plant Bioactives and Drug Discovery
Principles, Practice, and Perspectives
Wiley Series in Drug Discovery and Development Series

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today.

With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications.

Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Contributors xv

Preface xix

1 Natural Products in Drug Discovery: Recent Advances 1
Gordon M. Cragg, Paul G. Grothaus, and David J. Newman

2 Modern Approaches in the Search for New Active Compounds from Crude Extracts of Natural Sources 43
Emerson F. Queiroz, Kurt Hostettmann, and Jean-Luc Wolfender

3 Natural Products as Lead Compounds in Medicinal Chemistry 81
Eliezer J. Barreiro, Carlos A. M. Fraga, and Lidia M. Lima

4 The Importance of Structural Manipulation of Natural Compounds in Drug Discovery and Development 127
Arturo San Feliciano, María Á. Castro, José L. López-Pérez, and Esther del Olmo

5 The Action of Plants and their Constituents on the Central Nervous System 161
Fúlvio R. Mendes, Giuseppina Negri, Joaquim M. Duarte-Almeida, Ricardo Tabach, and Elisaldo A. Carlini

6 The Role of Natural Products in Discovery of New Anti-Infective Agents with Emphasis on Antifungal Compounds 205
Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, and Susana Zacchino

7 Antiulcer Agents from Higher Plants 241
Luiz C. Klein-Júnior, José R. Santin, and Sérgio F. de Andrade

8 Recent Progress in the Chemistry and Biology of Paclitaxel (Taxol^TM) and Related Taxanes 263
Jun Qi, Jielu Zhao, and David G. I. Kingston

9 Cancer Chemopreventive Activity of Higher Plants 337
A. Douglas Kinghorn, Yulin Ren, Jie Li, and Chung Ki Sung

10 Medicinal Plants and Pharmaceutical Technology 359
Ruth M. Lucinda da Silva, Angélica G. Couto, and Tania M.B. Bresolin

11 Natural Products in Clinical Trials 395
Sigrun Chrubasik

12 The Influence of Biotic and Abiotic Factors on the Production of Secondary Metabolites in Medicinal Plants 419
Dayana R. Gouvea, Leonardo Gobbo-Neto, and Norberto P. Lopes

13 Production of Bioactives Compounds: The Importance of Pictet–Spengler Reaction in the XXI Century 453
Pilar Menendez, Ilaria D’Acquarica, Giuliano Delle Monache, Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone, Alberto Boffi, Alessandra Bonamore, and Bruno Botta

14 Screening Methods for Drug Discovery from Plants 489
Alan L. Harvey

15 Phytotherapeutics – Intellectual Property Rights, Global Market, and Global Regulatory Guidelines 499
James D. McChesney, Raymond Cooper, and Kip Vought

16 Cooperation Between the Pharmaceutical Industry and Academic Institutions in Drug Discovery 529
Valdir Cechinel-Filho, Rivaldo Niero, and Rosendo A. Yunes

Acknowledgments 542

References 542

Index 545

Valdir Cechinel-Filho, PhD, is Professor and Researcher at the Chemical-Pharmaceutical Investigations Center, University of Vale do Itajaí in Brazil. The editor of five books, seventeen contributed chapters, and over 250 scientific papers and reviews, Dr. Filho is also Associate Editor of Pharmaceutical Biology, a member of the editorial boards of several journals, and a reviewer for many journals, including European Journal of Medicinal Chemistry, Journal of Pharmacy and Pharmacology, Natural Product Research, Planta Medica, and Journal of Agricultural and Food Chemistry.