RNA Metabolism in Mitochondria, Softcover reprint of the original 1st ed. 2018
Nucleic Acids and Molecular Biology Series, Vol. 34

Coordinators: Cruz-Reyes Jorge, Gray Michael W.

Language: English

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RNA Metabolism in Mitochondria
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Approximative price 147.69 €

In Print (Delivery period: 15 days).

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RNA Metabolism in Mitochondria
Publication date:
Support: Print on demand
This volume focuses on mitochondrial RNA metabolism, emphasizing recent discoveries and technological advances in this fast moving area that increase our understanding of mitochondrial gene function. Topics addressed include the interplay of mitochondria with the nucleus and cytosol, structure-function connections, and relevance to human disease. Mitochondria are the powerhouses of the cell, and a great deal is known about mitochondrial energy metabolism. Less well known is the plethora of amazing mechanisms that have evolved to control expression of mitochondrial genomes. Several RNA processes and machineries in protozoa, plants, flies and humans are discussed, including: transcription and RNA polymerase mechanism; tRNA processing of 5? and 3? ends; mRNA maturation by nucleotide insertion/deletion editing and by RNA splicing; mRNA stability; and RNA import. Specialized factors and ribonucleoproteins (RNPs) examined include pentatricopeptide repeat (PPR) proteins, RNase P, polymerases, helicases, nucleases, editing and repair enzymes. Remarkable features of these processes and factors are either not found outside mitochondria, differ substantially among eukaryotic lineages, or are unique in biology.  

Chapter 1

The Mitochondrial Transcription Machinery

Chapter 2

Mitochondrial RNA Turnover in Metazoa

Chapter 3

Mitochondrial RNase P Complex in Animals: Mitochondrial tRNA Processing and Links to Disease

Chapter 4 

Intercompartment RNA Trafficking in Mitochondrial Function and Communication

Chapter 5 

Control Mechanisms of the Holo-Editosome in Trypanosomes

Chapter 6 

Mitochondrial RNA Editing and Processing in Diplonemid Protists

Chapter 7 

Mechanisms and Evolution of tRNA 5′-editing in Mitochondria.

Chapter 8 

Editing of Mitochondrial RNAs in Physarum polycephalum.

Chapter 9 

Requirement of Various Protein Combinations for each C-to-U RNA Editosome in Plant Organelles


Dr. Jorge Cruz-Reyes, Department of Biochem. & Biophysics, and Department of Genetics. Texas A&M University and Texas AgriLife Research (AgriLife), College Station, Texas, USA.
Email: cruzrey@tamu.edu

Jorge Cruz-Reyes is a Professor in the Department of Biochemistry & Biophysics, and Department of Genetics, Texas A&M University (TAMU). 

Since he joined the faculty at TAMU in 2001 he has carried out studies of the RNA editing apparatus and mechanism in trypanosome mitochondria. More recently he began working on the development of lead compounds against in T. brucei and T. cruzi and molecular genetics of the potential targets. His multi-disciplinary research involves collaborations with several labs at TAMU and in other Universities in the USA and abroad. 

He obtained a Master's degree in Biomedical Research from the Institute of Biotechnology in UNAM, Mexico. He received a Ph.D. in Molecular Parasitology from the London School of Hygiene and Tropical Medicine, University of London. His interest in RNA biology and a prestigious Pew Fellowship Award led him to The Johns Hopkins School of Medicine, where he joined the lab of Barbara Sollner-Webb to work on trypanosome RNA editing during his postdoctoral training. Currently, he teaches courses in Molecular Genetics and RNA Biology. He also regularly serves in scientific review groups at the NIH and the NSF.

Dr. Michael W. Gray, Dalhousie University Dept. Biochem. & Molecular Biol. and Centre for Comparative Genomics and Evolutionary Bioinformatics (CGEB), Halifax, Nova Scotia, Canada.  Email: m.w.gray@dal.ca

Michael W. Gray is Professor Emeritus in the Department of Biochemistry and Molecular Biology, Dalhousie University (Halifax, Nova Scotia, Canada), which he joined in 1970, serving as head from 2004 to 2007. Since 1970, he has carried out research on the s

Highlights recent advances in mitochondrial RNA metabolism

Increases the understanding of mitochondrial gene function

Spans from mitochondrial interaction with nucleus and cytosol to human disease