Silkworm Biofactory
Silk to Biology

Industrial Biotechnology Series

Coordinators: Maenaka Katsumi, Park Enoch Y.

Language: Anglais

Approximative price 216.06 €

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· 15.6x23.5 cm · Hardback

While silk derived from silkworm has been of economic importance for centuries, more recently silkworm has been found to have utility in biomedicine. This has attracted attention for expressing eukaryotic recombinant proteins, which require post-translational modifications. In 1985 Dr. Susumu Maeda demonstrated that silkworm larvae could produce a functional human-interferon. Since then various techniques have been developed to express recombinant proteins in silkworm. With the development of the Bombyx mori nucleopolyhedrovirus (BmNPV) bacmid system, which is capable of replicating in both Escherichia coli and Bombyx mori derived cell lines or silkworm, silkworm larvae or pupae have been used for the expression system for recombinant protein production. This method has the advantage of a bacmid, in that it can be easily prepared for sufficient bacmid DNA for subsequent expression in silkworm. It is potentially a big breakthrough in production of recombinant eukaryotic proteins and viruses, which will be a powerful tool in a new proteome era.

This volume contributes to the advancement of our knowledge in the subject, for example gene expression systems and silkworm research, and focuses on silkworm biofactories for the recombinant protein production and commercial applications of proteins.




Basic and Applied Genetics of Silkworms

Toru Shimada

Silkworm Breeding

Yuyin Chen

Focus on Physiological Vital Proteins from Silkworm, Bombyx mori

Raman Chandrasekarand S. K. M. Habeeb

Metabolism of Molting Hormone and Juvenile Hormone in Silkworm

Yungen Miao

Post-translational Modification in Silkworm

Sungjo Park, Enoch Y. Park,and Andre Terzic



Glycoprotein biosynthesis of silkworm


BacMam System in Silkworm

Takashi Tadokoro

Transgenic Silkworm

Hideki Sezutsu

Glycosyltransferase Expression in Silkworm and Its Applications in Glycobiology

Makoto Ogata, Taichi Usui, and Enoch Y Park


Silkworm Expression of Cell Surface Molecules.

Shunsuke Kita

Expression and Purification of Mitochondrial Membrane Protein OPA1 for Reconstitution of Membrane Fusion

Tadato Ban and Naotada Ishihara

Virus-like Particles Expression in Silkworms

Vipin Kumar Deoand Enoch Y. Park



Gene Delivery Based on Bombyx mori Nucleopoplyhedrovirus (BmNPV)

Tatsuya Kato and Enoch Y. Park

Development of New Biomaterials from Insect and its Virus

Eiji Kotani and Hajime Mori


Production of Medical and Cosmetic Products Using Transgenic Silkworms.

Masahiro Tomita

Comparative Investigation of Influenza Virus-like Particles from Synthetic Chemical Substance and Silkworm

Kuniaki Nerome, Kazumichi Kuroda, and Shigeo Sugita


Production of Feline and Canine Interferon from Silkworm

Tsuyoshi Tanaka, Takashi Tanaka