Snake Venoms

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Language: Anglais
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In recent years, the field of Toxinology has expanded substantially. On the one hand it studies venomous animals, plants and micro organisms in detail to understand their mode of action on targets. While on the other, it explores the biochemical composition, genomics and proteomics of toxins and venoms to understand their three interaction with life forms (especially humans), development of antidotes and exploring their pharmacological potential. Therefore, Toxinology has deep linkages with biochemistry, molecular biology, anatomy and pharmacology. In addition, there is a fast developing applied subfield, clinical toxinology, which deals with understanding and managing medical effects of toxins on human body. Given the huge impact of toxin-based deaths globally, and the potential of venom in generation of drugs for so-far incurable diseases (for example, Diabetes, Chronic Pain), the continued research and growth of the field is imminent. This has led to the growth of research in the area and the consequent scholarly output by way of publications in journals and books. Despite this ever growing body of literature within biomedical sciences, there is still no all-inclusive reference work available that collects all of the important biochemical, biomedical and clinical insights relating to Toxinology. The Handbook of Toxinology aims to address this gap and cover the field of Toxinology comprehensively.
Toxinology of Snake Venoms: The Malaysian Context. - Cellular Mechanisms of Action of Snake Phospholipase A2 Toxins. - Secreted Phospholipases A2 with β-Neurotoxic Activity. - Anticoagulant and Membrane Damaging Properties of Snake Venom Phospholipase A2 Enzymes. - Phospholipase A2 Inhibitors from Snake Blood (sbPLIs). - A Brief Appraisal on Russell’s Viper Venom (Daboia russelii russelii) Proteinases. - Endothelial Cell Toxicity of Vascular Apoptosis-Inducing Proteins from Hemorrhagic Snake Venom. - Snake Venom Protease Inhibitors: Enhanced Identification, Expanding Biological Function, and Promising Future. - Snake Venom Toxins Targeted at the Nervous System. - Snake α-neurotoxins and the Nicotinic Acetylcholine Receptor. - Structural and Functional Diversity of Snake Sarafotoxins. - Crotamine: Function Diversity and Potential Applications. - Vipericidins, Snake Venom Cathelicidin-Related Peptides, in the Milieu of Reptilian Antimicrobial Polypeptides. - Cytotoxic Effects of Snake Venoms. - Cobra Venom Factor: The Unique Component of Cobra Venom That Activates the Complement System. - Non-Cobra Venom Factor Venom Components Acting on Complement Proteins. - Snake Venom Components Affecting the Coagulation System. - Snake Venom Disintegrins. - Role of Lymphatic System on Snake Venom Absorption. - Antivenom Safety and Tolerance for the Strategy of Snake Envenomation Management.

Complete and comprehensive overview of toxinology

Written by a very large team of experts from all around the world

Covers all areas of toxinology, including topics like bioterrorism, toxin evolution and toxin based drug development