Description
The Clinibook, clinical gene transfer state of the art
Author: COHEN-HAGUENAUER Odile
Language: EnglishSubjects for The Clinibook, clinical gene transfer state of the art:
Publication date: 11-2012
· 17x24 cm · Paperback
Out of Print
· 17x24 cm · Paperback
Out of Print
Description
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This book provides a 2012 reference for state-of-the-art gene transfer
technology and the different aspects of its clinical translation with a
focus on European-based initiatives. As examples of successful outcomes,
recent clinical trials are presented together with Ethical, Safety and
Regulatory issues, which are discussed. The broad range of various
technologies is covered whether addressing direct in vivo gene transfer
like with AAV, Adeno or non-viral vectors or ex-vivo genetically
engineered cells including induced pluripotent stem cells (iPS) with
integrating vectors such as retrovirus, lentivirus or transposon-derived
systems. The critical path to clinical implementation is covered in the
second part describing currently available tools - such as molecular
imaging, ex-vivo organ cultures and high-throughput technologies used for
evaluation of criteria towards a go-or-no go decision to move to the
clinic; in addition, utmost salient biosafety and immunotoxicology aspects
are discussed. This book is ideal for postgraduates, undergraduates,
scientists, clinicians, regulators and patients' advocacy groups looking
for states-of-the-art information as well as emerging prospects -
including gene targeting and homologous recombination - in gene transfer
intended for clinical translation.
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