Umbilical Cord Blood Banking and Transplantation, 2014
Stem Cell Biology and Regenerative Medicine
Stem Cell Biology and Regenerative Medicine Series

This comprehensive volume discusses the current scope of umbilical cord blood transplantation (UCBT), including recent controversies and future developments for improving clinical outcomes. Its twenty chapters introduce new applications in regenerative medicine and discuss the latest scientific, regulatory, clinical and investigational aspects of cord blood banking. Physicians from around the world provide a global collaboration which explores strategies for umbilical cord blood expansion, homing, unit selection, and combining of graft sources to improve patient outcomes. Umbilical Cord Blood Banking and Transplantation also reviews advances in pediatric UCBT for hematologic and non-hematologic disorders as well as immune recovery, which is critical to preventing infection. Finally, it compares UCBT with other graft sources in an attempt to understand the optimal graft source for the individual patient.  

UCBT is an important option for many patients who need a transplant but do not have a family donor or a matched unrelated donor. The collective and timely  knowledge presented here is essential reading for any regenerative medicine investigator, cord blood banker, transplant laboratory scientist or clinical physician interested in improving and expanding the applications of umbilical cord blood.

1. Applications of Umbilical Cord Blood Derived Stem Cells in Vascular Medicine.- Wouter Van’t Hof,Ph D and Mary J. Laughlin, MD.- 2. Regenerative Potential of Cord Blood.- Jessica M. Sun, MD and Joanne Kurtzberg, MD.- 3 Quality Control in Cord Blood Banking .- Monica B. Pagano, MD and N. Rebecca Haley, MD.- 4 Maternal HLA typing and Cord Blood Unit Choice.- Andromachi Scaradavou, MD.- 5 Optimizing Donor and Cord Blood Unit Selection for Banking and Transplantation.- Kristin M. Page, MD and Joanne Kurtzberg, MD.- 6 Cord Blood Transplantation for Pediatric Hematologic Malignancies: Indications, Mechanisms, and Outcomes.- Heather E. Stefanski, MD and Michael R. Verneris, MD.- 7 Results of Cord Blood Transplantation in Children with Non-Malignant Hematologic Conditions.- Kristin M. Page, MD, Suhag Parikh, MD, and Joanne Kurtzberg, MD.- 8 Umbilical Cord Blood Transplantation for Inherited Metabolic Diseases.- Vinod K Prasad, MD   .- 9 Myeloablative Single-Unit Cord Blood Transplantation in Adults.- Jun Ooi, MD.- 10 Quantitative and Qualitative Immune Reconstitution Following Umbilical Cord Blood Transplantation.- Sarah Nikiforow, MD and Jerome Ritz, MD.- 11 Thymic Regeneration after Umbilical Cord Blood Transplantation: Mechanisms, Measurements and Implications on Anti-viral Immunity.- Ioannis Politikos, MD and Vassiliki A. Boussiotis, MD.- 12 Cord Blood Transplantation in the East Mediterranean Region.- Mouhab Ayas, MD, Ardeshir Ghavamzadeh, MD, Mahmoud AljurfMD, Amir Ali Hamidieh,MD, and Amal Alseraihy, MD.- 13 Targeting Homing to Enhance Engraftment following Umbilical Cord Blood Stem Cell Transplantation.- Tyler Davis, MD and Sherif S Farag, MD, PhD.- 14 Cord Blood Ex-Vivo Expansion.- Paolo F. Caimi, MD, Leland Metheny, MD and Marcos de Lima, MD.- 15 Intra-Bone Marrow Transplant of Cord Blood Cells: A Transplant approach that tries to Optimize Seeding Efficiency and Trafficking of Hematopoietic Stem Cells.- Francesco Frassoni, Francesca Bonifazi, Marina Podestà, Giuseppe Bandini, Daniela Cilloni, and GianMario Sambuceti.- 16 Haplo Cord Transplantation : Overcoming the Limitations of Umbilical Cord Blood Transplantation.- Koen Van Besien, MD.- 17 Studies Comparing Haploidentical and Cord Blood Transplantation.- Christopher G Kanakry, MD and Ephraim J Fuchs, MD.- 18 Comparison of Umbilical Cord Blood to Adult Related and Unrelated Donors.- Areej El-Jawahri, MD and Yi-Bin Chen, MD.- 19 Disease Specific Analysis of Cord Blood Transplantation for Adults and Clinical Results of Single and Double Umbilical Cord Blood Transplantation.- Vanderson Rocha, MD, PhD.- 20 Selection of the Optimal Cord Blood Unit.- Karen Ballen, MD

Dr. Karen Ballen received her MD at Dartmouth College and then completed an Internal Medicine internship and residency at Beth Israel Deaconess Medical Center, Boston, and a Hematology/Oncology fellowship at Brigham and Women's Hospital, Boston. She has held several attending physician appointments including Transplant Physician, Brigham and Women's Hospital and Children's Hospital, Boston; Director, Bone Marrow Transplant Unit, UMass Memorial Health Care; and Acting Division Director, Medical Oncology, UMass Memorial Health Care. Dr. Ballen is currently a Full Professor in the Department of Medicine, Harvard Medical School, and director of the leukemia program, Massachusetts General Hospital. Her research interests focus on novel therapies for leukemia and transplantation. A particular area of specialty is cord blood transplantation for those patients who do not have matched related or unrelated donors. Dr. Ballen’s research has focused on improving outcomes after cord blood transplantation, and she has led multiple clinical trials focusing on double cord blood transplantation in adults, cord blood homing strategies, graft vs. host disease prophylaxis and infection prophylaxis. She has authored more than 100 papers in this field.

Comprehensive and detailed overview of umbilical cord blood (UCB) transplantation from optimal selection of the UCB unit, transplant outcomes for malignant & non-malignant diseases, and much more

Discusses significant related issues like recent controversies in public cord blood banking

Includes a section that focuses on future developments to improve outcomes

Includes supplementary material: sn.pub/extras