Vibrational Spectroscopy in Protein Research
From Purified Proteins to Aggregates and Assemblies

Coordinators: Ozaki Yukihiro, Baranska Malgorzata, Lednev Igor, Wood Bayden R.

Language: Anglais

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480 p. · 19.1x23.5 cm · Paperback

Vibrational Spectroscopy in Protein Research offers a thorough discussion of vibrational spectroscopy in protein research, providing researchers with clear, practical guidance on methods employed, areas of application, and modes of analysis. With chapter contributions from international leaders in the field, the book addresses basic principles of vibrational spectroscopy in protein research, instrumentation and technologies available, sampling methods, quantitative analysis, origin of group frequencies, and qualitative interpretation. In addition to discussing vibrational spectroscopy for the analysis of purified proteins, chapter authors also examine its use in studying complex protein systems, including protein aggregates, fibrous proteins, membrane proteins and protein assemblies.

Emphasis throughout the book is placed on applications in human tissue, cell development, and disease analysis, with chapters dedicated to studies of molecular changes that occur during disease progression, as well as identifying changes in tissues and cells in disease studies.

  • Provides thorough guidance in implementing cutting-edge vibrational spectroscopic methods from international leaders in the field
  • Emphasizes in vivo, in situ and non-invasive analysis of proteins in biomedical and life science research more broadly
  • Contains chapters that address vibrational spectroscopy for the study of simple purified proteins and protein aggregates, fibrous proteins, membrane proteins and protein assemblies

1. Vibrational imaging of proteins; changes in the tissues and cells in life style diseases studies 2. Detection of proteins associated with disease using vibrational spectroscopy 3. NIR Imaging studies of proteins in fish egg development 4. Raman studies of fibrous proteins 5. AFM-IR on protein aggregation 6. Two-dimensional correlation spectroscopy of proteins 7. FT-IR studies of photosynthesis proteins 8. Secondary structure of proteins studied by ROA 9. Single proteins placed within the SERS hot spots of self-assembled silver nanolenses 10. ATR-IR imaging of proteins 11. TERS of DNA and proteins 12. DUV resonance studies of proteins 13. VCD of protein fibrils 14. Biomedical application of vibrational spectroscopy: proteins 15. Probing proteins with UV resonance Raman spectroscopy 16. ROA of proteins 17. Nonlinear correlation spectroscopy of proteins 18. Multidimensional Infrared Spectroscopy for elucidating protein structure and function (dynamics) 19. Model Protein Embedded in Solid Lipid 20. SERS In vivo intracellular monitoring and imaging of relevant cytoplasm metabolites under different conditions 21. Molecular spectroscopy studies of molecular changes that occur during disease progression and to instigate rapid objective biofluid diagnostics

Active researchers and students in biochemistry, molecular biology, pharmaceutical science, cellular biology, applied microbiology, and biotechnology; medical chemists; clinician scientists
Dr. Ozaki received his B.Sc. in Chemistry in 1973 and PhD in Physical and Inorganic Chemistry in 1978, both from Osaka University. After over two years at the National Research Council of Canada as a research associate, he joined Jikei University School of Medicine in Tokyo. In 1989, he became associate professor and later full professor in the Chemistry Department at Kwansei Gakuin University until March 2018. He was a Vice President of Kwansei Gakuin University from April 2013 to March 2018. Currently Professor Ozaki is a professor emeritus of Kwansei Gakuin University. Ozaki has received many awards, including the 1998 Tomas Hirschfeld Award, 2001 EAS Award for Achievements in Near Infrared Spectroscopy, 2002 Spectroscopical Society of Japan Award, 2005 Science and Technology Award of Japanese Government, 2008 Japan Society for Analytical Chemistry Award, 2014 Bomem-Michelson Award, 2017 Chemical Society of Japan Award, and the 2018 Medal with Purple Ribbon.
Dr. Malgorzata Baranska leads the Raman Imaging Group at The Jagiellonian University, Kraków, Poland. In her research, Dr. Baranska focuses on analyzing bioactive compounds using spectroscopic methods, particularly modern Raman techniques. The main direction of her research is related to development treatments for life style diseases, including new drugs of endothelium bioactivity.
Dr. Igor Lednev received his PhD degree from The Moscow Institute of Physics and Technology, Russian Federation before joining the University of Albany as faculty. As an academic visitor, he worked in several leading laboratories around the world including the United Kingdom, Japan, Canada, and Germany. Dr. Lednev’s current research is focused on the development and application of novel laser spectroscopy for biomedical and forensic applications.
Dr. Bayden R. Wood is an Australian Research Council Future Fellow working at the Centre for Biospectroscopy located in the School of Chemistry, Monash University, Malborne, Aust