DNA Repair and Cancer
From Bench to Clinic

DNA repair is a rapidly advancing field in biology. DNA repair systems represent a major defense mechanism against environmental and intracellular damaging agents, such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. In particular, it provides essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.

Overview of DNA Repair Pathways. Longevity Assurance by Genome Maintenance. Genome Instability of Cancer: Biological Predictions and Clinical Implications. Radiation Induced DNA Damage, Repair and Therapeutics. Chemotherapeutic Alkylating Agents in Cancer Treatment. O6-Methylguanine-DNA Methyltransferase (MGMT) in Cancer Protection and Therapy. DNA Mismatch Repair: It’s Role in Human. Carcinogenesis and as a Predictive and/or Prognostic Biomarker for Cancer Therapy. DNA Base Excision Repair Therapeutics: Summary of Targets with a Focus on APE1. Nucleotide Excision Repair: DNA Repair Capacity Variability and Cancer. Susceptibility. Fanconi Anemia, Interstrand Cross-link Repair and Cancer. Functions of Translesion DNA Polymerases: Implications for Cancer Risk and Opportunities as Therapeutic Targets. p53 in DNA Damage, Repair and Cancer Therapeutics. ATM/ATR Cell Cycle Checkpoints: Mechanisms and Manipulation in Cancer Therapy. The BRCA1-BRCA2 Pathway of Homologous Recombination and the Opportunity for Synthetic Lethal Approaches to Cancer Therapy. PARP and PARP Inhibitor Therapeutics. Tumor Genetics and Personalized Medicine. The Tumor Microenvironment and DNA Repair: Implications for Cancer Progression and Treatment. Early Phase Clinical Trials using DNA Repair Inhibitors: Lessons Learnt.