International Manual of Oncology Practice (2^nd Ed., 2nd ed. 2019)
iMOP - Principles of Oncology

Cancer is a very aggressive disease and currently it has been considered a challenge to oncologists and cancer patients worldwide. Nowadays, several therapeutic strategies had improved toward last decades. Surgery is many times still the best curative treatment, mainly in early stage disease. However, Radiotherapy and chemotherapy acquired a main role in this scenario. Target therapies were introduced for medical oncology practice and are demonstrating a hallmark of a new era in cancer treatment. More recently, immunotherapy has been considered the novel cornerstone in cancer treatment. The 2^nd edition of the International Manual of Oncology Practice (iMOP) emerged after the great success of the iMOP 1^st edition as a reference for medical oncologists and medical residents in the field. In this edition, several chapters were revised and its addresses from the molecular issues of cancer sciences to the clinical practice in medical oncology. In addition, multiple choice questions and clinical cases were included in the main chapters in order to improve the reader learning. The book focuses systemic treatments in many areas of medical oncology, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. The topics herein discussed will provide the readers a step forward in the medical oncology practice understanding and give facilities for help in cancer patient treatments.   

1

Cancer screening and epidemiology

R.A. De Mello

ramello@ualg.pt or ramondemello@doctors.org.uk

UALG, Portugal

2

Cancer stem cells

José Bragança

jebraganca@ualg.pt 

UALG, Portugal

3

Apoptosis

Richard Hill

richard.hill@port.ac.uk

UALG, Portugal

4

Angiogenesis

Patrícia Madureira

pamadureira@ualg.pt

UALG, Portugal

5

Genetic basis of metastasis

Mehmet Gunduz

mehmet.gunduz@gmail.com

Turgut Ozal University, Turkey

6

Anti-cancer Drugs

Wolfgang Link

walink@ualg.pt

UALG, Portugal

7

Immuno-oncology

Pedro Madureira

ramondemello@gmail.com

ICBAS Portugal

8

Health Econimics

nelsonteich@americasoncologia.com.br

Américas Oncologia, Rio de Janeiro, Brazil

PART II – SOLID TUMORS

THORACIC

9

Non-Small Cell Lung cancer

A. Tantraworasin

ohm_med@hotmail.com

Chiang Mai University, Thailand

10

Small cell lung cancer

A. Tantraworasin

ohm_med@hotmail.com

Chiang Mai University, Thailand

11

Mesothelioma

Vangelis Karamitrousis

v-a-g-@hotmail.com

Alexandroupolis, Greece

12

Thymus

Hakaru Tadokoro

ramondemello@gmail.com

UNIFESP, Brazil

BREAST

 13

Breast

Ines Monteiro

ines.pcmonteiro@gmail.com

Lausanne, Switezerland

GASTROINTESTINAL

14

Karima Oualla

Fes, Marroco

15

Gastric

Luis Castelo-Branco

luismocb@hotmail.com

Faro, Portugal

16

Colon

Nora Forones

noraforones@gmail.com

UNIFESP, Brazil

17

Rectal

JInhui Zhu

ramondemello@gmail.com 

China

18

Anal Canal Cancer

ramondemello@gmail.com

UNIFESP, Brazil

19

Small intestine

Pedro Aguiar Jr

pnajpg@hotmail.com

20

Liver Cancer

R. A. DE Mello

ramondemello@gmail.com

UNIFESP, Brazil

21

Pancreatic Cancer

George Antoniou

dr.antoniou@gmail.com

GYNECOLOGICAL TUMORS

22

Ovarian

Renata Justa

renatajusta@gmail.com

ICC, Brazil

23

Cervical

Alvaro Henrique Ingles Garces

alvarohenriq@yahoo.com.br

INCA, Brazil

24

Vagina

Nikolaou Michail

nikolaoumike@hotmail.com

Larissa, Greece

25

Gestacional trophoblastic disease

Donald Peter Goldstein

DGOLDSTEIN@partners.org

Boston, MA, USA

GENITO-URINARY

Prostate Cancer

Arlindo Ferreira

ajrsferreira@gmail.com

Lisboa, Portugal

27

Renal Cell Carcinoma

fernando.nunes@clion.com.br

Salvador, Brazil

28

Urothelial Cancer

ryaacoub@uci.edu

California, USA

29

Germ-Cell Tumors

Giannis Mountzios

gmountzios@gmail.com

29.1

Penile Cancer

Nikolaos Tsoukalas

tsoukn@yahoo.gr

London, UK

Squamous Head and neck

jean-pascal.machiels@uclouvain.be

Brussels, Belgium

31

Thyroid cancer

wwgois@gmail.com

Fortaleza, Brazil

32

Parotid Gland Tumors

José Aurillo Rocha

jaurillo@hotmail.com

SKIN, SOFT TISSUE, BONE, GIST AND ENDOCRINE

Melanoma

paolo.ascierto@gmail.com

Napoli, Italy

34

Soft Tissue Sarcomas

Carlos Marcio

carlossmarcio@gmail.com

Fortaleza, Brazil

35

Bone Sarcomas

Hakaru Tadokoro

ramondemello@gmail.com

UNIFESP, Brazil

36

GIST

R. A. De Mello

ramondemello@gmail.com

Brazil/Switzerland

37

NET

Yim KL

yimkl2000@hotmail.com

Cardiff, UK

38

Primary brain tumor

Hakaru Tadokoro

ramondemello@gmail.com

UNIFESP, Brazil

PART III – HEMATO-ONCOLOGY

39

Acute Lymphoblastic Leukemia

Eddy Supriyadi

e.supriyadi@gadjahmada.edu  

Indonesia

40

Myelodisplastic Syndrome

Ronald Feitosa

ronaldfpinheiro@uol.com.br

Fortaleza, Brazil

PART IV – PALLIATIVE CARE AND SUPPORTIVE CARE

41

Metabolic disturbance/paraneoplasic syndromes

Carmélia Barreto

carmeliabarreto@gmail.com

Sao Paulo, Brazil

Spinal medular compression

ramondemello@gmail.com

43

Superior vena cava syndrome

Maria Tolia

mariatolia1@gmail.com   

Larissa, Greece

44

Febrile neutropenia

Bora Lim

naborala@gmail.com

Texas, USA

45

Chemotherapy-Induced Nausea and Vomiting

Rudolph M. Navari

rmnavari@gmail.com

Indiana University School of Medicine South Bend, USA

46

Asthenia

F. Koinis

phillipkoinis@gmail.com

Athens, Greece

47

Oncological pain

R.A. De Mello

ramondemello@gmail.com

UALG, Portugal

48

Bone Metastases

Arlindo Rebelo-Ferreira

arjsferreira@gmail.com 

Lisbon, Portugal

49

Brain metastasis

Tiago Pádua Costa

tiagopadua1@hotmail.com

São Paulo, Brazil

50

Palliative care

Débora Galdêncio

debora_galgencio@yahoo.com.br

Manaus, Brazil

Ramon Andrade de Mello, MD, PhD

University of Algarve, Portugal

Ramon Andrade Bezerra de Mello received the MD degree at the Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil, with MD recognition from University of Lisbon, Portugal, and holds the Certificate in Medical Oncology by passing the European examination of ESMO (European Society for Medical Oncology), Lugano, Switzerland. He completed specialization in medicine and molecular oncology and his PhD in Oncology (lung cancer) at the Faculty of Medicine, University of Porto, Portugal. He also completed a post-doctoral clinical research fellowship in lung cancer clinical trials at the Lung Unit, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom, supported by the ESMO. Currently, he works in the Department of Medical Oncology at the Portuguese Oncology Institute, Porto, Portugal, and he teaches at the Department of Medicine of the University of Porto and School of Medicine, University of Algarve, Faro, Portugal. He is medical director of Oncoclínica/Euroclinics, Porto, Portugal. Prof. de Mello performs both basic and clinical research on angiogenesis, palliative medicine, internal medicine, colorectal cancer and lung cancer; further, he has an active office working. He is editor of 2 books (Tamoxifen Concepts and Cancer: New Paradigms and Vimentin Concepts and Molecular Mechanisms, Nova Science, NY, USA, 2013), author of several scientific articles, chapters and comments on basic and clinical research. He presented more than 50 papers in congresses and conferences in several countries, such as United States, Sweden, Brazil, Portugal and Spain. Furthermore, he serves as editorial board of several reputed scientific journals, such as PLoS ONE, Rare tumors, Oncology Reviews and scientific reviewer of the British Journal of Cancer, Journal of Thoracic Oncology, Annals of Internal Medicine and The Lancet. He participates as expert reviewer of grant applications

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