Laboratory Exercises in Molecular Pathology

Coordinators: Homeister Jonathon W., Coleman William B., Tsongalis Gregory J.

Language: English

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400 p. · 21.6x27.6 cm · Hardback

Laboratory Exercises in Molecular Pathology is organized by major organ systems and disease type, presenting exercises that distill essential disease-specific information (related to frequency, risk factors, disease manifestations) and a description of disease pathogenesis (molecular and cellular) that is based upon accepted principles from today's literature. Each exercise is illustrated with (1) gross specimens, (2) microscopic histopathology, (3) immunohistochemistry and/or in situ hybridization (when applicable), (4) laboratory techniques to probe the molecular nature of the pathological lesions, and (5) molecular diagnostics (when applicable).

In addition, each exercise contains one or more cases studies to provide students with exposure to the clinical workup of a patient that are based upon physical examination findings, traditional pathological analysis, and state-of-the-art molecular assessment.

The laboratory techniques included emphasize the dissection of molecular and cellular pathogenesis of the disease in question. Hence, students will see examples of laboratory results that illustrate how pathways were elucidated. Further, the sections on molecular diagnostics illustrate how molecular testing exploits what is known about molecular pathogenesis in a specific disease setting.



  • Presents foundational information with examples of gross and microscopic pathology and molecular approaches and testing
  • Offers an ancillary website with videos corresponding to the evaluation of gross specimens, the assessment of microscopic images, and a demonstration of laboratory techniques
  • Features exercises which contain one or more cases studies to provide students with exposure to the clinical workup of a patient
  • Provides case studies which include self-assessment modules and decision trees that allow students to make mistakes and then receive explanations
Section 1. Disorders of the Cardiovascular System
Section 2. Disorders of Blood and Bone Marrow
Section 3. Disorders of the Respiratory System
Section 4. Diseases of Infection
Section 5. Diseases of the Gastrointestinal System
Section 6. Disorders of the Liver and Exocrine Pancreas
Section 7. Disorders of the Kidney and Urinary System
Section 8. Disorders of the Female Reproductive System
Section 9. Disorders of the Male Reproductive System
Section 10. Disorders of the Endocrine System
Section 11. Disorders of the Skin, Bones, and Connective Tissue
Section 12. Disorders of the Central and Peripheral Nervous Systems
Biomedical graduate students studying disease and translational aspects of basic science; post-doctoral researchers and medical residents/fellows in pathology and laboratory medicine
Jonathon W. Homeister earned Bachelor of Arts degrees in Biology and Chemistry in 1985 from Hope College, where he began his research endeavors mentored by Christoper C. Barney, Ph.D. He then earned the Doctor of Philosophy in Pharmacology, mentored by Benedict R. Lucchesi, M.D., Ph.D., and the Doctor of Medicine from the University of Michigan in 1993. He received residency training in anatomic pathology at the University of Michigan Hospitals and is a Diplomat of the American Board of Pathology. After residency, he received additional research training as an Associate of the Howard Hughes Medical Institute, mentored by John B. Lowe, M.D. He is currently an Associate Professor in the Department of Pathology and Laboratory Medicine, and member of the McAllister Heart Institute at the University of North Carolina at Chapel Hill, where he is also Director of the Molecular and Cellular Pathology Graduate Program. His clinical interests include cardiovascular, autopsy, and forensic pathology, and his research interests focus on the glycobiology inherent to leukocyte trafficking, with particular respect to the pathogenesis of cardiovascular diseases including atherosclerosis and thrombosis.
William B. Coleman, PhD is the Executive Officer for the American Society for Investigative Pathology (Rockville, MD). Prior to taking this position with the American Society for Investigative Pathology, Dr. Coleman spent 28 years at the University of North Carolina School of Medicine (Chapel Hill, NC), first as a postdoctoral fellow (1990-1995) and then as a faculty member (1995-2018) in the Department of Pathology and Laboratory Medicine. During his time at the UNC School of Medicine, Dr. Coleman served as Director of Graduate Studies for the Molecular and Cellular Pathology Ph.D. Program (2006-2012; now the Pathobiology and Translational Medicine Ph.D. Program), was a co-founder of the UNC Program in Translational Medicine and served as its Co-Director (2006-2015) and then its