Milestones in Immunology
Based on Collected Papers

Milestones in Immunology: Based on Collected Papers contains scientific milestones relating to the history of medicine over the past two centuries. The book highlights the contributions of pioneering scientists whose discoveries have paved the way for researchers working in the field of immunology. As the science of immunology grew from knowledge that survivors of common infectious diseases rarely contracted them again, the book uses this as a central thesis, helping readers understand how the adaptive immune system aids in defense against pathogens. In addition, the book covers special fields, such as immunohistochemistry, immunogenetics and immunopathology.

For the past century, immunology has fascinated and inspired some of the greatest scientists of our time. Numerous Nobel Prizes have been awarded for fundamental discoveries in immunology, from Paul Ehrlich? work on antibodies (1908) to the studies of Zinkernagel and Doherty (1986) elucidating mechanisms of cell-mediated immunity.

1. Paul Ehrlich’s doctoral thesis: a milestone in the study of mast cells2. Miller’seminal studies on the role of thymus in immunity3. The contribution of Bruce Glick to the definition of the role played by the bursa of Fabricius in the development of the B cell lineage4. The fundamental contribution of Robert A. Good to the discovery of the crucial role of thymus in mammalian immunity5. Giulio Bizzozero and the discovery of platelets6. Sir Frank Macfarlane Burnet and the clonal selection theory of antibody formation7. The embryonic origins of lymphatic vessels: an historical review8. The fundamental contribution of William Bate Hardy to shape the concept of mast cell heterogeneity9. The mast cell: an evolutionary perspective10. From the discovery of monoclonal antibodies to their therapeutic application: an historical reappraisal11. Max D. Cooper and the delineation of two lymphoid lineages in the adaptive immune system12. Edelman’s view on the discovery of antibodies13. Peter Brain Medawar and the discovery of acquired immunological tolerance14. The discovery of blood-thymus barrier

immunologists, Historians of Medicine, Philosophers of Science and Medicine, Students

• Provides on update on developments since the publication of Nobel prize winning research for fundamental discoveries in immunology
• Discusses the changing theories and technologies that guided the field
• Lists all the important discoveries and books in the field
• Explains, in detail, the many Nobel prize-winning contributions of immunologists
• Provides recognition of the scientists who were pioneers of landmark discoveries in immunology