Molecular and Cell Biology of Neuropsychiatric Diseases, Softcover reprint of the original 1st ed. 1994
Molecular and Cell Biology of Human Diseases Series

The fourth volume in the Molecular and Cell Biology of Neuropsychiatric Diseases series provides a comprehensive, timely review of the use of modern biological techniques in the investigation of the major neuropsychiatric diseases. The scope of the book is wide, and an introductory section at the beginning of each chapter enables non-specialist and specialist alike to appreciate the significance of this research.

1 Molecular biology of Huntington’s disease.- 1.1 Introduction.- 1.2 Linkage analysis.- 1.3 Recombination events.- 1.4 Linkage disequilibrium.- 1.5 Genomic imprinting.- 1.6 Predictive testing.- 1.7 Ethical considerations.- 1.8 Uptake of predictive testing.- 1.9 Counselling.- 1.10 Conclusion.- References.- 2 Neuronal pathology in relation to molecular biology and treatment of Alzheimer’s disease.- 2.1 Introduction.- 2.2 Neurotransmission.- 2.3 Glutamate, excitotoxicity and ?-amyloid.- 2.4 Drug therapies.- 2.5 Conclusions.- References.- 3 The aetiology of Alzheimer’s disease.- 3.1 General introduction.- 3.2 Aluminium.- 3.3 Viruses.- 3.4 DNA repair.- 3.5 Other possible risk factors.- 3.6 Epilogue.- Acknowledgements.- References.- 4 The molecular genetics of Alzheimer’s disease.- 4.1 Introduction.- 4.2 Genetic epidemiology.- 4.3 The molecular genetics of Alzheimer’s disease.- 4.4 Future studies.- References.- 5 The molecular biology of the transmissible dementias.- 5.1 Introduction.- 5.2 The infectious agent.- 5.3 The PrP gene and its expression.- 5.4 The PrP.- 5.5 Molecular genetics of the human transmissible dementias.- 5.6 Summary and concluding remarks.- References.- 6 The neurochemistry of schizophrenia.- 6.1 Serotonergic function in schizophrenia.- 6.2 Central noradrenergic function in schizophrenia.- 6.3 Dopamine and schizophrenia.- 6.4 Monoamine oxidase and schizophrenia.- 6.5 GABAergic function in schizophrenia.- 6.6 Neuropeptidergic function in schizophrenia.- 6.7 Glutamatergic systems in schizophrenia.- 6.8 Conclusions.- References.- 7 Molecular biology of schizophrenia.- 7.1 Introduction.- 7.2 Linkage studies.- 7.3 Cytogenetic anomalies and schizophrenia.- 7.4 Mutation analysis in schizophrenia.- 7.5 Summary.- References.- 8 Genetics and molecularbiology of manic-depression.- 8.1 Introduction.- 8.2 Clinical diagnosis and identification of the phenotype.- 8.3 Clinical genetics and models of transmission.- 8.4 Models of genetic transmission.- 8.5 Biological theories and possible candidate genes.- 8.6 Gene finding methods: genetic linkage and allelic association.- 8.7 Genetic (allelic) association analysis and its use in the major psychoses.- References.