Molecular Diagnostics for Dermatology, 2014
Practical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient

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Language: English
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Molecular Diagnostics for Dermatology. Practical Applications of Molecular Testing for the Diagnosis and Management of the Dermatology Patient
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356 p. · 17.8x25.4 cm · Hardback
Molecular diagnostics is an exploding field, and recent advances in our understanding of the molecular basis of disease have provided a platform for the development of new diagnostic tests as well as tests to predict tumor behavior and potential response to targeted therapy. This textbook provides a reference and practical guide to molecular diagnostics for dermatologists and dermatopathologists. It outlines our current understanding of the molecular underpinnings of dermatologic disease, describes the appropriate use of currently available molecular tests, and explains the interpretation of these tests in the context of diagnosis and management. Tests relating to various disorders are covered, including but not confined to melanoma, genodermatoses, and infectious disease. Pitfalls are highlighted and user-friendly algorithmic approaches, presented.
Introduction.- Terms and Definitions.- Basics of Molecular Biology and Nucleic Acids.- Principles of the Molecular Basis for Disease.- Molecular Testing Methods.- PCR and PCR-based Assays.- In situ Hybridization.- FISH and Cytogenetics.- Comparative Genomic Hybridization.- Microarray Analysis .- Melanoma.- Cutaneous Lymphoma and Leukemia Cutis.- Soft Tissue tumors.- Genodermatoses.- Infectious Disease.- Viral.- Bacterial and Mycobacterial.- Fungi and Parasites.- Emerging Molecular Applications in Dermatology.- Pharmacogenetics/Pharmacogenomics.- Theranostics.

Gregory A. Hosler studied chemical and biomedical engineering at Princeton University, and graduated magna cum laude in 1993. He subsequently earned his MD and PhD from the University of Texas Southwestern Medical Center before joining the Department of Pathology at The Johns Hopkins University School of Medicine in 2001. He returned to the University of Texas Southwestern Medical Center as Clinical Assistant Professor of Pathology and Dermatology in 2006. Since then, he has also worked at ProPath as a dermatopathologist and in molecular diagnostics. Dr. Hosler is an active member of the American Society of Dermatopathology, the Texas Society of Pathologists, and the American Academy of Dermatology, among others. He serves on numerous committees and regularly runs educational sessions at the annual meetings. In addition to the above speaking engagements, he has lectured at the World Congress of Dermatology and is a regular guest faculty lecturer at the annual Scripps Clinic Malignancy Update on Melanoma conference. He is on the Board of Directors of the Texas Society of Pathology and the Governing Board of ProPath. He is an editorial board member for ISRN Pathology and an ad hoc reviewer for a number of leading journals, including the Journal of Cutaneous Pathology. Dr. Hosler is the author of numerous publications in peer-reviewed journals. He is the Dermatopathology Fellowship Director at ProPath.

Kathleen M. Murphy earned a PhD from the Department of Microbiology and Immunology at the University of Louisville in 1999 and subsequently completed postdoctoral training in Molecular Pathology at The Johns Hopkins University School of Medicine. She joined the faculty at The Johns Hopkins University School of Medicine in 2001, where she advanced to the rank of Associate Professor in the Departments of Pathology and Oncology. She is currently Director of Clinical Laboratory Operations at ProPath Services, Dallas, Texas and also Adjunct Associate Professor in

Emphasis on practical applications of molecular testing in diagnosis and management

Offers insights into the interpretation of tests

Explains pitfalls and presents user-friendly algorithmic approaches

Includes bullet points highlighting key information for easy application