Neonatal Seizures
Current Management and Future Challenges
International Review of Child Neurology Series

Coordinator: Nagarajan Lakshmi

Language: English

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214 p. · 17.8x24.6 cm · Hardback

A better understanding of neural activity and the development of cortical connections and networks is an important requirement for evaluating the cause and treatment of neonatal seizures. There have been many advances in the management of neonatal seizures such as increased use of EEGs, therapeutic hypothermia for HIE and exome sequencing, to name a few. Neonatal Seizures, Current Management, Future Challenges distils what is known about these advances into one scholarly yet practical text.

AUTHORS' APPOINTMENTS vii

FOREWORD x

PREFACE xii

ACKNOWLEDGEMENTS xiii

1. DEVELOPMENT OF THE NEONATAL CEREBRAL CORTEX 1
Soumya Ghosh

2. THE ROLE OF THE VIDEO EEG IN NEONATES WITH SEIZURES 12
Lakshmi Nagarajan and Soumya Ghosh

3. RECORDING A VIDEO-EEG STUDY IN A NEONATE 30
Linda Palumbo and Lakshmi Nagarajan

4. THE ROLE OF AMPLITUDE-INTEGRATED EEG IN THE MANAGEMENT OF NEONATAL SEIZURES 40
Lena Hellström-Westas, Ingmar Rosén and Linda S. de Vries

5. ADVANCES IN NEUROPHYSIOLOGY AND NEONATAL SEIZURES: AUTOMATED SEIZURE DETECTION 56
Nathan J. Stevenson and Geraldine B. Boylan

6. NEUROIMAGING IN NEONATAL SEIZURES 76
Camilo Jaimes, Christos Papadelis and P. Ellen Grant

7. NEONATAL EPILEPSIES AND EPILEPTIC ENCEPHALOPATHIES 100
Maria Roberta Cilio

8. CLINICAL APPROACH TO A NEONATE WITH SEIZURES 114
Shripada Rao, Barry Lewis, Soumya Ghosh and Lakshmi Nagarajan

9. TREATMENT OF NEONATAL SEIZURES 128
Lakshmi Nagarajan

10. PREDICTORS OF NEURODEVELOPMENTAL OUTCOME IN INFANTS WITH NEONATAL SEIZURES 146
Lakshmi Nagarajan, Andrea Poretti, Thierry A G M Huisman and Soumya Ghosh

11. NEURODEVELOPMENTAL OUTCOMES OF NEONATES WITH SEIZURES 163
Jarred Garfinkle and Michael I Shevell

12. NEUROPROTECTIVE STRATEGIES FOR NEONATES WITH SEIZURES 172
Shilpa D. Kadam, Xiaohe Yu and Michael V. Johnston

INDEX 193

Neonatologists, paediatricians, neurologists, neurophysiology technologists, and other health professionals who care for neonates with seizures.
Professor Lakshmi Nagarajan is Consultant Neurologist/Epileptologist and Head of the Department of Neurology at the Princess Margaret Hospital for Children, Perth, Western Australia. She also runs the Comprehensive Epilepsy Programme for Children and Adolescents in Western Australia. Her research interests include neonatal seizures, childhood epilepsy, paediatric neurology and clinical neurophysiology. Prof Nagarajan is a member of the Board of Directors of the International Child Neurology Association and the Australian New Zealand Child Neurology Society. She has published close to 50 papers in peer reviewed journals.