Novel Insights on Oral Anticoagulants in Clinical Practice
Focus on Acenocoumarol

Anticoagulants are medicines that help prevent blood clots. They are given to people at a high risk of getting clots, to reduce their chances of developing serious conditions such as strokes and heart attacks (NHS Choices).

This book is a guide to the latest advances in oral anticoagulant therapy in clinical practice.

Divided into twenty sections, the book begins with an overview of coagulation and haemostasis, and the history and development of oral anticoagulants.

The following sections discuss the role of anticoagulation in different patient groups and disorders, including in pregnancy, in geriatric and paediatric patients, cancer, chronic kidney disease, valvular heart disease, and dental surgery. Both existing and new anticoagulants are covered, with emphasis on pharmacology and safety.

The final chapters of this practical reference explain food and drug interactions, challenges with anticoagulation, bleeding complications, and the role of patient education and counselling during therapy.

Key points

• Practical guide to latest advances in oral anticoagulant therapy
• Describes the history and development of anticoagulants
• Covers role of anticoagulation in different patient groups and disorders
• Discusses pharmacology and safety of both new and existing anticoagulants

1. Overview of Coagulation and Hemostasis
2. Anticoagulants: Oral and Parenteral Agents
3. Indications of Anticoagulation Therapy
4. Oral Anticoagulants: From Discovery to Clinical Practice
5. Vitamin K Antagonists in Thromboembolic Disorders
6. Tests for Monitoring Adequacy and Efficacy of Anticoagulation Therapy
7. Initiation and Maintenance of Vitamin K Antadonists Therapy
8. Anticoagulation in Non-Valvular Atrial Fibrillaion
9. Prevention and Management of DVT and PE, and Role of Vitamin K Antagonists
10. Anticoagulation in Valvular Heart Disease
11. Anticoagulation in Special Situations: Pregnancy
12. Anticoagulation in Special Populations: Geriatric and Pediatric
13. Anticoagulation in Special Situations: Cancer
14. Anticoagulation in Special Situations; Chronic Kidney Disease
15. Anticoagulation in Major and Minor Surgeries
16. Anticoagulation in Dental Surgeries
17. Bleeding Complications with Vitamin K Antagonists
18. Food and Drug Interactions
19. Real-World Challenges with Anticoagulation
20. Role of Patient Education and Counselling during Anticoagulation Therapy

Jagdish S Hiremath DM DNB FACC
Director, Cath Lab and Interventional Cardiologist, Ruby Hall Clinic, Pune, Maharashtra, India