Oral Microbiology and Immunology (3^rd Ed.)
ASM Books Series

The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.

Against this backdrop, the third edition of Oral Microbiology and Immunology has been substantially expanded and rewritten by an international team of authors and editors. Featured in the current edition are:

• links between oral infections and systemic disease
• revised and updated overview of the role of the immune system in oral infections
• thorough discussions of biofilm development and control
• more extensive illustrations and Key Points for student understanding

Graduate students, researchers, and clinicians as well as students will find this new edition valuable in study and practice. The field of oral microbiology has seen fundamental conceptual changes in recent years. Microbial communities are now seen as the fundamental etiological agent in oral diseases through their interface with host inflammatory responses. Study of structured microbial communities has increased our understanding of the roles of each member in the pathogenesis of oral diseases, principles that apply to both periodontitis and dental caries.

Contributors xxi

Preface xxv

About the Editors xxvii

Section I General Principles of Oral Microbiology and Immunology 1

1 General Microbiology 3
Howard F. Jenkinson

Key points 28

2 The Immune System and Its Functions 29
George Hajishengallis and Jonathan M. Korostoff

Key points 50

Further Reading 51

3 The Oral Environment 53
Frank A. Scannapieco and Stefan Ruhl

Key points 80

Further Reading 80

4 Isolation, Classification, and Identification of Oral Bacteria 81
Eugene J. Leys, Ann L. Griffen, and Clifford Beall

Key points 99

Further Reading 99

5 Oral Microbial Ecology 101
Howard F. Jenkinson and Richard J. Lamont

Key points 121

Further Reading 122

6 Oral Microbial Physiology 123
Paul G. Egland and Robert E. Marquis

Key points 147

Further Reading 147

7 Genetics and Molecular Biology of Oral Microorganisms 149
Angela H. Nobbs, Bing-Yan Wang, and Gena D. Tribble

Key points 187

Further Reading 188

8 Applied Molecular Biology and the Oral Microbes 189
Hansel M. Fletcher, Arunima Mishra, Sasanka Chukkapalli, Stuart Dashper, and Ann Progulske-Fox

Key points 211

Further Reading 212

9 Population Genetics of Oral Bacteria 213
Mogens Kilian

Key points 225

Further Reading 226

10 Immunology of the Oral Cavity 227
Evlambia Hajishengallis and George Hajishengallis

Key points 248

Further Reading 248

Section II Infection-Driven Oral Diseases 249

11 Dental Caries: Etiology and Pathogenesis 251
William H. Bowen, Livia M. A. Tenuta, Hyun Koo, and Jaime A. Cury

Key points 265

Further Reading 265

12 Pathogenic Mechanisms in Dental Caries 267
José A. Lemos, Hui Wu, Robert G. Quivey, Jr., and Hyun Koo

Key points 284

Further Reading 285

13 Periodontal Diseases: General Concepts 287
Panos N. Papapanou

Key points 307

Further Reading 307

14 Virulence Factors of Periodontal Bacteria 309
Richard J. Lamont, Janina P. Lewis, and Jan Potempa

15 Immunopathogenic Mechanisms in Periodontal Disease 333
George Hajishengallis

Key points 356

Further Reading 357

16 Oral Virology 359
Matti Sällberg

Key points 395

Further Reading 396

17. Fungi and Fungal Infections of the Oral Cavity 397
Richard D. Cannon, Ann R. Holmes, and Norman A. Firth

Key points 414

Further Reading 415

18 Endodontic Infections and Therapeutic Approaches 417
Brenda P. F. A. Gomes, Isabela N. Rôças, and José F. Siqueira, Jr.

Further Reading 432

19 Systemic Disease and the Oral Microbiota 433
Angela H. Nobbs and Mark C. Herzberg

Section III Control of Oral Diseases 455

20 Antibiotics: Mechanisms of Action, Resistance, and Clinical Use in Dentistry 457
Pin-Chuang Lai, Hyun Koo, Paul Stoodley, and John Walters

Key points 494

Further Reading 494

21 Therapeutic Approaches for Biofilm Control and Host Modulation in Oral Diseases 495
Yijin Ren, Henry C. van der Mei, George Hajishengallis, Hyun Koo, and Henk J. Busscher

Key points 522

Further Reading 522

22 Infection Prevention and Control in Dentistry 525
J. Christopher Fenno, Stephen J. Stefanac, and Brandonn K. Perry

Key points 549

Further Reading 550

Index 551