Principles of Bone Biology (4th Ed.)

Coordinators: Bilezikian John, Martin T. John, Clemens Thomas L., Rosen Clifford J.

Language: Anglais

Subject for Principles of Bone Biology

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1900 p. · 21.6x27.6 cm · Hardback

Principles of Bone Biology, Fourth Edition remains the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology. Assembled by experts from around the world, this book is designed for students interested in the field, young investigators at the graduate and post-graduate level beginning their research careers, and scientists investigating skeletal disorders who need to enrich their research programs.



  • Includes a repository of knowledge for anyone involved in the study of bone biology
  • Provides a one-stop source written by experts in the field

PART I - Basic Principles A. Cell Biology1. Endochondral and Intramembraneous Bone Development; 2. Mesenchymal Stromal Cells; 3. Hematopoietic-Bone Cell Interactions; 4. Osteoblasts; 5. Osteoclasts; 6. Osteocytes; 7. Transcriptional Control of Osteoblast Differentiation; 8. Wnt Signaling and Bone Cell Activity; 9. Vascular and Nerve Interactions; 10. Coupling of Bone Formation and Resorption; 11. Bone Remodeling; 12. Aging and Bone

B. Biochemistry 13. Type I Collagen Structure, Synthesis, and Regulation; 14. Collagen Cross-Linking and Metabolism; 15. Noncollagenous Bone Matrix Proteins (including osteopontin); 16. Bone Proteinases; 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells; 18. Intercellular Junctions and Cell–Cell Communication in the Skeletal System

C. Bone Remodeling and Mineral Homeostasis19. Histomorphometric Analysis of Bone Remodeling; 20. Phosphorus Homeostasis and Related Disorders; 21. Magnesium Homeostasis; 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lanthanum, Lead, Silicon, and Strontium; 23. Biology of the Extracellular Ca2+-Sensing Receptor

D. Endocrine and Paracrine Regulation of Bone 24. Parathyroid Hormone: Molecular Biology; 25. Paracrine PTHrP in Bone: Physiology and Pharmacology; 26. Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System and Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein; 27. PTH and PTHrP Actions on Kidney; 28. Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein; 29. 1α,25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses; 30. Vitamin D Gene Regulation; 31. Noncalcemic Actions of Vitamin D; 32. Cellular Actions of Parathyroid Hormone; 33. Calcitonin peptides; 34. Regulation of Bone Remodeling by Central and Peripheral Nervous

E. Other Systemic Hormones that Influence Bone Metabolism35. Estrogens and Progestins; 36. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues; 37. The Pharmacology of Selective Estrogen Receptor Modulators; 38. Thyroid Hormone and Bone; 39. Clinical and Basic Aspects of Glucocorticoid Action in Bone; 40. Androgens Receptor Expression and Steroid Action in Bone

F. Local Regulators41. Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology; 42. Platelet-Derived Growth Factor and the Skeleton; 43. Notch Signaling and its Ligands; 44. Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone; 45. Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling; 46. Transforming Growth Factor-β; 47. Bone Morphogenetic Proteins and the Skeleton and Bone Morphogenetic Protein Receptors and Actions; 48. Non-Skeletal Actions of RANK Ligand; 49. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-γ, the LIF/IL-6 Family, and Additional Cytokines; 50. Prostaglandins and Bone Metabolism

PART II – Molecular Mechanisms of Metabolic Bone Disease 51. Molecular Actions of PTH1R and their implications; 52. Multiple Endocrine Neoplasia Type 1; 53. Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy; 54. Localized Osteolysis; 55. Genetic Regulation of Parathyroid Gland Development; 56. Genetic Disorders Caused by PTH/PTHrP Receptor Mutations; 57. Molecular Basis of PTH Overexpression; 58. Diseases Resulting from Defects in the G Protein Gsα; 59. Renal Osteodystrophy: Pathogenic Mechanisms and Therapeutic Options; 60. Osteogenesis Imperfecta; 61. Hereditary Deficiencies in Vitamin D Action; 62. FGF 23; 63. Tumor-Induced Osteomalacia; 64. Osteopetrosis; 65. Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans; 66. Paget's Disease of Bone; 67. Genetic Determinants of Bone Mass and Osteoporotic Fracture / Genomic Approaches in Skeletal Research

PART III – Pharmacological Mechanisms of Therapeutics 68. Pharmacological Mechanisms of Therapeutics: Parathyroid Hormone; 69. Calcium; 70. Drugs Acting on the Calcium Receptor: Calcimimetics and Calcilytics; 71. Bisphosphonates: Mechanisms of Action; 72. Pharmacologic basis of RANK L inhibition; 73. Pharmacologic basis of Sclerostin Inhibition; 74. Vitamin D and Analogues; 75. Mechanisms of Exercise

PART IV – Methods in Bone Research 76. Application of Genetically Modified Animals in Bone Research; 77. Biochemical Markers of Bone Metabolism; 78. Microimaging; 79. Macroimaging; 80. Methods in Lineage Tracing; 81. Histomorphometry in Rodents; 82. Bone Strength Testing in Rodents; 83. Endocrinology of Bone

Biomedical researchers, research clinicians, graduate students, and fellows in the fields of endocrinology, bone biology, osteology, and rheumatology