Description
Translational Research Methods in Diabetes, Obesity, and Nonalcoholic Fatty Liver Disease (2nd Ed., 2nd ed. 2019)
A Focus on Early Phase Clinical Drug Development
Coordinators: Krentz Andrew J., Weyer Christian, Hompesch Marcus
Language: EnglishSubjects for Translational Research Methods in Diabetes, Obesity, and...:
556 p. · 17.8x25.4 cm · Hardback
Description
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This book aims to aid the selection of the most appropriate methods for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, non-alcoholic fatty liver disease (NAFLD) and related cardiometabolic disorders.
Clinical research methods to assess the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycemic clamp technique, have become well-established in proof-of-mechanism studies. However, selection of the most appropriate techniques is by no means straightforward. Moreover, the application of such methods must conform to the regulatory requirements for new drugs.
This book discusses the need for new pharmacotherapies for diabetes, obesity and NAFLD and the molecular targets of drugs currently in development. Emerging technologies including functional imaging, circulating biomarkers and omics are considered together with practical and ethical issues pertaining to early phase clinical trials in subjects with cardiometabolic disorders.
Translational Research Methods in Diabetes, Obesity, and Non-Alcoholic Fatty Liver Disease is of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Contains new chapters of how treatment can be applied for major disease areas
Provides a background to aid the understanding of drug effects and non-drug treatment strategies on key biochemical-hormonal defects of obesity and type 2 diabetes
Aids the selection of the most appropriate techniques for assessing insulin action, insulin secretion and body composition in humans?
Provides practical examples to assist usage/applications, explanation and study analysis
Perils and pitfalls are summarized for each technique