The World of Nano-Biomechanics (2nd Ed.)
Mechanical Imaging and Measurement by Atomic Force Microscopy

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Language: English
Cover of the book The World of Nano-Biomechanics

Subject for The World of Nano-Biomechanics

Keywords

Adhesion; AFM; -alanine; Antigen-antibody; Atomic force microscopy (AFM)Biomembrane force probe; Bioconjugates; Biological polymers; Biomechanics; Biotin-avidin; Cantilever sensor; Carbonic anhydrase; Catch bond; Cell membrane; Cell movement; Cell shape; Cell stiffness; Cell surgery; Covalent bond; Creep relaxation; Cytoskeleton; Data analysis; Dipole moment; Dispersion force; DNA overstretching; DNA recovery; DNA stretching; DNA unzipping; DNA�protein interaction; DNA; Dynamic stretching; Electrostatic interaction; End-to-end distance; FEM; Finite element; Flagella; Force (on Human body)Friction; Force modulation; Force spectroscopy; Freely jointed chain (FJC)Persistence length; Gel columns; Gene manipulation; Gravity; Hertz model; High-throughput measurements; Hydrodynamic drag; Hydrogen bond; Hydrophobic interaction; Imaging; Indentation experiment; Knotted proteins; Laser trap; Lenard-Jones potential; Lipid-protein; Liposomes; Loading rate dependence; Magnetic beads; Mechanical breakdown; Mechanical properties; Mechanics; Membrane breaking; Membrane deformation; Membrane protein extraction; Membrane proteins; Modular proteins; Molecular and cellular mechanical properties; Morphology; Motor proteins; Muscle; Mycoplasma; Nanomedicine; Non-covalent bond; Poisson's ratio; Polyethylene; Poly-l; Polymer pullout; Power-law rheology; Protein anchoring; Protein compression; Protein stretching; Protein; Proteins in Motion; Receptor mapping; Red blood cell; Rigidity of protein; RNA recovery; Shear modulus; Single-cell mechanical diagnostics; Soft materials; Strain; Stress relaxation; Stress; Structural design; Sugar-lectin; Surface force apparatus; Tatara model; Tissue surgery; Transferrin-receptor; Viscosity; Wheat germ agglutinin (WGA)Wormlike chain (WLC)Young's modulus

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The World of Nano-Biomechanics, Second Edition, focuses on the remarkable progress in the application of force spectroscopy to molecular and cellular biology that has occurred since the book's first edition in 2008. The initial excitement of seeing and touching a single molecule of protein/DNA is now culminating in the development of various ways to manipulate molecules and cells almost at our fingertips, enabling live cell operations.

Topics include the development of molecular biosensors, mechanical diagnosis, cellular-level wound healing, and a look into the advances that have been made in our understanding of the significance of mechanical rigidity/flexibility of protein/DNA structure for the manifestation of biological activities.

The book begins with a summary of the results of basic mechanics to help readers who are unfamiliar with engineering mechanics. Then, representative results obtained on biological macromolecules and structures, such as proteins, DNA, RNA, polysaccharides, lipid membranes, subcellular organelles, and live cells are discussed. New to this second edition are recent developments in three important applications, i.e., advanced AFM-data analysis, high-resolution mechanical biosensing, and the use of cell mechanics for medical diagnosis.

1. Force in Biology2. Introduction to Basic Mechanics3. Force Measurement and Mechanical Imaging Apparatuses4. Interaction Forces5. Polymer Chain Mechanics6. Analysis of Data Gleaned by Atomic-Force Microscopy7. Single–Molecular Interaction8. Single-Molecule DNA and RNA Mechanics9. Single-Molecule Protein Mechanics10. Nanomechanics of Motion-Supporting Molecular Systems11. Finite-Element Analysis of Microbiological Structures12. Nanomechanical Bases of Cell Structure13. Nanorheology of Living Cells14. Molecular and Cellular Manipulations for Future Nanomedicine

Graduate students and researchers in biophysics, biochemistry, and molecular and cell biology; and biomedical engineers
Professor Atsushi Ikai graduated from the University of Tokyo with a BS in Biophysics and Biochemistry in 1965. He obtained his PhD in Physical Biochemistry from Duke University in 1971. He worked in protein denaturation and renaturation and then returned to the University of Tokyo to continue his work on protein science. He was appointed Professor of Biodynamics at Tokyo Institute of Technology in 1989. He has published 300 articles in international scientific journals.
  • Explains the basic physical concepts and mathematics of elementary mechanics needed to understand and perform experimental work on small-scale biological samples
  • Presents recent developments of force-based biosensing
  • Includes novel applications of nano-biomechanics to the medical field