Advanced Topics in Forensic DNA Typing: Interpretation

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Language: English
Cover of the book Advanced Topics in Forensic DNA Typing: Interpretation

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Keywords

2p Rule; ABI Genetic Analyzer; Administrative review; Allele Drop-In; Allele Drop-Out; Allele Dropout; Allele Frequencies; Allelic Ladder; Analytical Threshold; Assumptions; Binary Method; CPI/CPE; Capillary electrophoresis; Casework reports; Combined Probability Of Exclusion; Combined Probability Of Inclusion; Communication; Complex Mixture; Complex Mixtures; Component Deconvolution; Concordance Study; Confidence Intervals; DNA Mixture; DNA Profile; Data Collection; Data Interpretation; Data Models; Disaster Victim Identification; Drawing conclusions; Dye Color Balance; Electrokinetic injection; Electropherogram; Familial Searching; Fluorescence detection; Fully Continuous Method; Haploid Markers; Hardy-Weinberg Equilibrium; Hypothesis Testing; ISFG DNA Commission; ISFG Recommendations; Immigration Testing; Kinship Analysis; Kit Validation Studies; LCN; LTDNA; Likelihood Ratio; Lineage Markers; Linkage Disequilibrium; Locus-To-Locus Balance; Low-Level DNA; Low-Template DNA; Major Contributor; Match Probability; Minor Contributor; Missing Persons Investigations; Mitochondrial DNA; Mixture; Mixture Deconvolution; Modified Random Match Probability (mRMP); Noise; Non-Template Addition; Null Allele; PCR Multiplex Reactions; PCR artifacts; Parentage Testing; Partial Profile; Peak Height Ratio; Population Database; Population Substructure; Probabilistic Genotyping; Probability; Product Rule; Profile Frequency; Random Man Not Excluded (RMNE); Random Match Probability; Relationship Testing; Relatives; Report writing; Restricted vs; STR Allele; STR Genotype; STR Profiles; STR Typing; Semi-Continuous Method; Sibship Testing; Signal; Size Standard; Source Attribution; Standard Operating Procedure (SOP); Statistics; Stochastic Threshold; Stutter Product; Technical review; Threshold; Tri-Allelic Patterns; Troubleshooting; Unrestricted Genotype Combinations; Validation; Validation Data; Variant Allele; Weight-of-Evidence; X-Chromosome; Y-Chromosome

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608 p. · 19x23.4 cm · Hardback

Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler?s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions.

Section 1: DATA INTERPRETATION Chapter 1: Data Interpretation Overview Chapter 2: Data, Models & Thresholds Chapter 3: STR Alleles & Artifacts Chapter 4: STR Genotypes Chapter 5: STR Profiles Chapter 6: DNA Mixtures Chapter 7: Low-Level DNA & Complex Mixtures Chapter 8: Troubleshooting Data Collection

Section 2: STATISTICAL INTERPRETATION Chapter 9: Statistical Interpretation Overview Chapter 10: STR Population Data Analysis Chapter 11: DNA Profile Frequency Estimates Chapter 12: DNA Mixture Statistics Chapter 13: Coping with Missing Alleles Chapter 14: Relationship Testing Chapter 15: Lineage Marker Statistics Chapter 16: Laboratory Reports: Communicating Results and Conclusions

APPENDICES Appendix 1: STR Allele Frequencies from U.S. Population Data Appendix 2: NRC I and NRC II Recommendations Appendix 3: DAB Recommendations on Statistics Appendix 4: Worked mixture example (by Dr. Michael D. Coble)

Researchers and practitioners in forensic DNA analysis, forensic scientists; legal professionals, military, private and public forensic laboratories, forensic science graduate and post-graduate students.

John M. Butler is a NIST Fellow and Special Assistant to the Director for Forensic Science, Office of Special Programs, at the U.S. National Institute of Standards and Technology, in Gaithersburg, Maryland. Dr. Butler earned his PhD from the University of Virginia while doing DNA research in the FBI Laboratory's Forensic Science Research Unit. He has won numerous scientific awards, including being named Science Watch’s #1 world-wide high-impact author in legal medicine and forensic science over the last decade (July 2011). He has over 150 publications in this field and is a frequent presenter on the topic of DNA typing, and has authored four other DNA Typing books including Advanced Topics in Forensic DNA Typing: Methodology. For a detailed CV, visit http://www.cstl.nist.gov/strbase/butler.htm.
  • Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence
  • Worked mixture examples illustrate the impact of different statistical approaches for reporting results
  • Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011