Angiogenesis, Softcover reprint of the original 1st ed. 2000
From the Molecular to Integrative Pharmacology
Advances in Experimental Medicine and Biology Series, Vol. 476

Proceedings of the 5th Biannual International Meeting on Angiogenesis: From the Molecular to Integrative Pharmacology, held July 1-7, 1999, in Crete, Greece.
Angiogenesis, as a vastly complex biological process, has challenged researchers from all basic scientific disciplines, including pharmacology, biochemistry, physiology, embryology and anatomy. The significance of this phenomenon for the study of disease states has also interested clinicians from a number of specialist fields. This multidisciplinary work reflects the growth of awareness of concepts such as angiogenesis based therapy, the enormous therapeutic and commercial potential of which has attracted major research and investment in recent years. This volume, which aims to bridge the gap between basic and clinical methodology and understanding, presents the most up-to-date developments in this field.

Introductory Comments.- Angiogenic Factors and Their Receptors.- Examining New Models for the Study of Autocrine and Paracrine Mechanisms of Angiogenesis through FGF2-Transfected Endothelial and Tumour Cells.- Tie-1 Receptor Tyrosine Kinase Endodomain Interaction with SHP2: Potential Signalling Mechanisms and Roles in Angiogenesis.- On the Mechanism(s) of Thrombin Induced Angiogenesis.- Endothelial Receptor Tyrosine Kinases in Involved Blood Vessel Development and Tumor Angiogenesis.- Ontogeny of the Endothelial System in the Avian Model.- Regulation of Angiogenesis and Transduction Mechanisms Involved.- The Role of Pericytes in Controlling Angiogenesis In Vivo.- Insights into the Vasodilation of Rat Retinal Vessels Evoked by Vascular Endothelial Growth Factor121 (VEGF121).- Signal Transduction and Transcriptional Regulation of Angiogenesis.- Differential Contribution of Bradykinin Receptors in Angiogenesis.- Sensitivity of Different Vascular Beds in the Eye to Neovascularization and Blood-Retinal Barrier Breakdown in VEGF Transgenic Mice.- Revascularization of Ischemic Tissues with SIKVAV and Neuropeptide Y (NPY).- Cellular Effects and Signalling Pathways Activated by the Anti-Coagulant Factor Protein S in Vascular Cells.- Role of Extracellular Matrix and Adhesion Molecules in Angiogenesis.- Targeting Integrins avb3 and avb5 for Blocking Tumor-Induced-Angiogenesis.- Suppression of Human Microvascular Endothelial Cell Invasion and Morphogenesis with Synthetic Matrixin Inhibitors.- Inhibitors of Angiogenesis and their Mechanisms of Action.- Tunicamycin Inhibits Capillary Endothelial Cell Proliferation by Inducing Apoptosis.- The Characterization of Angiogenesis Inhibitor from Shark Cartilage.- Quantitative Assays for the Chick Chorioallantoic Membrane.- Angiogenesis andMalignant Transformation.- MYCN Oncogene and Angiogenesis: Down-Regulation of Endothelial Growth Inhibitors in Human Neuroblastoma Cell.- From Hyperplasia to Neoplasia and Invasion: Angiogenesis in the Colorectal Adenoma - Carcinoma Model.- Tumor Angiogenesis Macrophages Cytokines.- Microvessel Density Thymidine Phosphorylase Expression and Resistance of Head and Neck Cancer to Chemo-Radiotherapy.- Differential Expression of Angiogenic and of Vascular Survival Factors in Non-Small Cell Lung Cancer (NSCLC).- Thymidine Phosphorylase Activity in Normal Hyperplastic and Neoplastic Endometrium-Correlation with Intratumoral Angiogenesis.- Preclinical Developments of Angiogenesis Inhibitors.- Inhibition of VEGF Signal Transduction.- Combretastatins: Novel Vascular Targeting Drugs for Improving Anti-Cancer Therapy.- Clinical Applications.- Therapeutic Angiogenesis for Ischemic Heart Disease.- Abstracts of Posters.- Participants’ Photo.- List of Participants.