Description
Contributions of Physiology to the Understanding of Diabetes, Softcover reprint of the original 1st ed. 1997
Ten Essays in Memory of Albert E. Renold
Coordinators: Zahnd Gaston R., Wollheim Claes B.
Language: EnglishSubjects for Contributions of Physiology to the Understanding of Diabetes:
Publication date: 10-2013
173 p. · 15.5x23.5 cm · Paperback
173 p. · 15.5x23.5 cm · Paperback
Description
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Recent developments in research on diabetes mellitus embrace basic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heterogeneous diabetic syndrome are oriented towards regulatory principles of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events implicated in selective destruction of pancreatic ß-cell. In parallel, efforts are made for a better understanding of normal versus impaired biological actions, both of insulin and insulin-like growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.
Thoughts on the Regulation of Adenylyl Cyclase Systems by Hormone-Sensitive G-Proteins: A Tribute to Albert E. Renold.- Anabolic Response to Cell Swelling in the Liver.- Intercellular Communication and Insulin Secretion.- Expression of the Insulin Gene and Its Regulation.- Implications of the Glucokinase Glucose Sensor Paradigm for Pancreatic ?-Cell Function.- How Ca2+ and Other Signalling Pathways Control the Exocytosis of Insulin in the ?-Cell.- The Mechanism of Insulin Receptor Binding, Activation and Signal Transduction.- Cell Biology of Insulin Action on Glucose Transport: Looking Back.- Insulin-like Growth Factor: Endocrine and Autocrine/Paracrine Implications and Relations to Diabetes Mellitus.- On the Pathogenesis of Insulin-Dependent Diabetes Mellitus in Man: A Paradigm in Transition.- Selected References from the Bibliography of Albert E. Renold, M.D.
Recent developments in research on diabetes mellitus embrace ba- sic disciplines such as physiology, biochemistry, morphology and evolving sub-specialities. Fundamental studies on the heteroge- neous diabetic syndrome are oriented towards regulatory princi- ples of cell metabolism, genetic control mechanisms of insulin biosynthesis and secretion, as well as autoimmune events impli- cated in selective destruction of pancreatic á-cell. In paral- lel, efforts are made for a better understanding of normal ver- sus impaired biological actions, both of insulin and insulin-li- ke growth factor I, and the translocation process of glucose transporters in insulin-responsive target cells.
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