Essential Concepts in Molecular Pathology

Coordinators: Coleman William B., Tsongalis Gregory J.

Language: Anglais
Cover of the book Essential Concepts in Molecular Pathology

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536 p. · 21.6x27.9 cm · Hardback

This streamlined "essential" version of the Molecular Pathology (2009) textbook extracts key information, illustrations and photographs from the main textbook in the same number and organization of chapters. It is aimed at teaching students in courses where the full textbook is not needed, but the concepts included are desirable (such as graduate students in allied health programs or undergraduates). It is also aimed at students who are enrolled in courses that primarily use a traditional pathology textbook, but need the complementary concepts of molecular pathology (such as medical students). Further, the textbook will be valuable for pathology residents and other postdoctoral fellows who desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school.

  • Offers an essential introduction to molecular genetics and the "molecular" aspects of human disease
  • Teaches from the perspective of "integrative systems biology," which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease
  • In-depth presentation of the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease using histopathology.
  • "Traditional" pathology section provides state-of-the-art information on the major forms of disease, their pathologies, and the molecular mechanisms that drive these diseases.
  • Explains the practice of "molecular medicine" and the translational aspects of molecular pathology: molecular diagnostics, molecular assessment, and personalized medicine
  • Student web site hosts "self-assessment" questions; Professor web site hosts all figures from book
  • Each chapter ends with Key Summary Points and Suggested Readings

    PART I Essential Pathology - Mechanisms of Disease

    Chapter 1 Cell Injury, Cell Death, and Cellular Adaptation

    John J. Lemasters, M.D., Ph.D.

    Chapter 2 Acute and Chronic Inflammation

    Vladislav Dolgachev, Ph.D. and Nicholas W. Lukacs, Ph.D.

    Chapter 3 Infection and Host Response

    Sheldon M. Campbell, M.D., Ph.D. and Margret Oethinger, M.D.,Ph.D.

    Chapter 4 Neoplasia

    William B. Coleman, Ph.D., and Tara Rubinas, M.D.

    PART II Concepts in Molecular Biology and Genetics

    Chapter 5 Basic Concepts in Human Molecular Genetics

    W. Edward Highsmith, Ph.D., and Kara A. Mensink, M.S., C.G.C.

    Chapter 6 The Human Genome: Implications for the Understanding of Human Disease

    William B. Coleman, Ph.D, Gregory J. Tsongalis, Ph.D. and Ashley Rivenbark, M.D.

    Chapter 7 The Human Transcriptome: Implications for the Understanding of Human Disease

    Reinhold Schafer, Ph.D., Matthias E. Futschik, Ph.D., Wolfgang Kemmner, Ph.D., and Christine Sers, Ph.D.

    Chapter 8 The Human Epigenome: Implications for the Understanding of Human Disease

    Manel Esteller, Ph.D. and Maria Berdasco, Ph.D.

    Chapter 9 The Human Proteome: Implications for the Understanding of Human Disease

    Lance Liotta, Ph.D., Virginia Espina, Claudia Fredolini, Weidong Zhou, and Emanuel Petricoin

    Chapter 10 Integrative Systems Biology: Implications for the Understanding of Human Disease

    M. Michael Barmada, Ph.D. and David C. Whitcomb

    PART III Principles and Practice of Molecular Pathology

    Chapter 11 Pathology: The Clinical Description of Human Disease

    William K. Funkhouser, M.D., Ph.D.

    Chapter 12 Molecular Pathogenesis: The Biological Basis of Human Disease

    William B. Coleman, Ph.D, and Gregory J. Tsongalis, Ph.D.

    Chapter 13 Integration of Molecular and Cellular Pathogenesis

    Jason H. Moore, Ph.D., and C. Harker Rhodes, M.D.

    PART IV Molecular Pathology of Human Disease

    Chapter 14 Molecular Basis of Cardiovascular Disease

    Avrum I. Gotlieb, M.D.C.M. and Amber Chang Liu

    Chapter 15 Molecular Basis of Hemostatic and Thrombotic Diseases

    Nigel S. Key, M.D., and Alice Ma, M.D.

    Chapter 16 Molecular Basis of Lymphoid and Myeloid Diseases

    Dong-Er Zhang, Ph.D. and Joseph Biggs, Ph.D.

    Chapter 17 Molecular Basis of Diseases of Immunity

    David O. Beenhouwer, Ph.D.

    Chapter 18 Molecular Basis of Pulmonary Disease

    Dani S. Zander, M.D., and Carol Farver, M.D.


    Chapter 19 Molecular Basis of Diseases of the Gastrointestinal Tract

    Antonio Sepulveda, M.D., Ph.D. and Dara L. Aisner, M.D., Ph.D.

    Chapter 20 Molecular Basis of Liver Disease

    Satdarshan P. Singh Monga, M.D. and Jaideep Behari, M.D.

    Chapter 21 Molecular Basis of Diseases of the Exocrine Pancreas

    Markus M. Lerch, M.D.

    Chapter 22 Molecular Basis of Diseases of the Endocrine System

    Malcolm M. Martin, M.D., Arlene L. Martin, M.D., Alan L.Y. Pang, Ph.D., and Wai-Yee Chan, Ph.D.

    Chapter 23 Molecular Basis of Gynecologic Diseases

    Samuel Chi-ho Mok, Ph.D., Kwong-Kwok Wong, Ph.D., Karen Lu, M.D., Karl Munger, Ph.D., and Zoltan Nagymanyoki, Ph.D.

    Chapter 24 Molecular Pathogenesis of Diseases of the Kidney

    Amy K. Mottl, M.D., M.P.H., and Carla Nester, M.D., M.S.A.

    Chapter 25 Molecular Basis of Prostate Disease

    William G. Nelson, M.D., Ph.D., Angelo M. De Marzo, M.D., Ph.D., and Carlise R. Bethel, M.D., Ph.D.

    Chapter 26 Molecular Basis of Breast Disease

    Christos Sotiriou, M.D., Ph.D., Natasha Snoj, Phuong Dinh, and Philippe Bedard

    Translational Research Unit, Jules Bordet Institute, Universite Libre de Bruxelles, Brussels, Belgium

    Chapter 27 Molecular Basis of Skin Disease

    John A. McGrath, Ph.D., and Vesarat Wessagowit, M.D., Ph.D.

    Chapter 28 Molecular Basis of Diseases of the Nervous System

    Joshua A. Sonnen, M.D., C. Dirk Keene, M.D., Robert F. Hevner, M.D., and Thomas J. Montine, M.D., Ph.D.

    PART V Practice of Molecular Medicine

    Chapter 29 Molecular Diagnosis of Human Disease

    Grant Bullock, M.D., Ph.D., and Lawrence M. Silverman, Ph.D.

    Chapter 30 Molecular Assessment of Human Disease in the Clinical Laboratory

    Gregory J. Tsongalis, Ph.D. and Joel A. Lefferts, M.D.

    Chapter 31 Pharmacogenomics and Personalized Medicine in the Treatment of Human Disease

    Gregory J. Tsongalis, Ph.D. and Hong Kee Lee, Ph.D.

    Medical students, graduate students in allied health programs, undergraduate students; pathology residents and other postdoctoral residents and fellows interested in the molecular mechanisms of disease.