Fertility Preservation in Male Cancer Patients

Men with cancer rendered infertile by surgery, chemotherapy, radiation and hormone therapy that are needed to control or cure their disease are increasingly being offered the chance to preserve their reproductive potential through artificial reproductive technologies. Cryopreservation of sperm and testicular tissue have increasingly helped boys and men preserve their fertility. There is a growing subspecialty within reproductive medicine aimed at fertility preservation in this population. Furthermore, strategies are being developed that may in the future revolutionize the approach to such patients. Written by international authorities in the field of fertility preservation, this comprehensive book is aimed at clinicians dealing with male cancer patients, in particular, urologists, andrologists, oncologists, pediatricians and nursing staff as well as clinicians in reproductive endocrinology. The text reviews the impact of cancers and their treatment on male fertility, the available fertility preservation strategies and post-treatment management.

Preface; Part I. Anatomy and Physiology: 1. Functional anatomy of the hypothalamic-pituitary-testis axis and male reproductive tract Nelson E. Bennett, Jr; 2. Spermatogenesis Kathleen Hwang, Alex Ridgeway and Dolores J. Lamb; 3. The semen analysis Mary K. Samplaski and Edmund S. Sabanegh, Jr; 4. Physiology of ejaculation François Giuliano and Pierre Clément; Part II. Disorders of Male Fertility: 5. History and physical examination Ndidiamaka Onwubalili and Hossein Sadeghi-Nejad; 6. Abnormalities of semen parameters Daniel H. Williams IV and Jay I. Sandlow; 7. Azoospermia Cara B. Cimmino and Robert D. Oates; 8. Varicocele Peter J. Stahl and Marc Goldstein; 9. Disorders of ejaculation Doron S. Stember and John P. Mulhall; 10. Androgen deficiency in the male Gregory C. Mitchell and Wayne J. G. Hellstrom; 11. Infertility and male sexual dysfunction Raanan Tal; Part III. Impact of Cancers and Treatment of Male Fertility: 12. Radiation effects on spermatogenesis Fabio Firmbach Pasqualatto and Ashok Agarwal; 13. Chemotherapy: effects on spermatogenesis Akanksha Mehta and Mark Sigman; 14. Effects of therapy for solid tumors Gretchen A. Gignac and Leonard H. Wexler; 15. Lymphoma and leukemia Eytan Stein and Ariella Noy; 16. Stem cell transplantation Ann A. Jakubowski; 17. Fertility preservation in men with germ cell tumors Matthew T. Roberts and Keith Jarvi; 18. Effects of therapy for brain cancer Elena Pentsova and Andrew B. Lassman; 19. Male infertility following childhood cancer: special considerations for fertility preservation in children Mark F. H. Brougham and W. Hamish B. Wallace; Part IV. Preservation Strategies: 20. Facilitating discussion about fertility preservation Gwendolyn P. Quinn and Susan T. Vadaparampil; 21. Development of a program to address fertility preservation and parenthood after cancer treatment Joanne Frankel Kelvin; 22. Psychological consultation and assessment Linda D. Applegarth; 23. Nutraceuticals in fertility preservation Mark A. Moyad; 24. Application of spermatogenesis suppression therapies for fertility preservation Rian J. Dickstein, Gunapala Shetty and Marvin L. Meistrich; 25. Semen cryobiology and sperm banking Helen R. Levey and Bruce R. Gilbert; 26. Ethical and legal considerations of sperm and tissue cryopreservation Melissa B. Brisman and Lauren Murray; 27. The use of ejaculation induction procedures in cancer patients Dana A. Ohl, Mikkel Fode, Nancy L. Brackett, Charles M. Lynne, Susanne A. Quallich and Jens Sønksen; 28. Sperm extraction in the pre-therapy patient Wayland Hsiao and Peter N. Schlegel; 29. Fertility preservation in the pediatric population: germ cell culture and transplantation Kate H. Kraft and Thomas F. Kolon; 30. Exogenous androgens: effect on spermatogenesis Mohit Khera; 31. Fertility preservation in the female with cancer Kenny A. Rodriguez-Wallberg and Kutluk Oktay; Part V. Post-therapy Considerations: 32. Psychological issues surrounding the use of sperm donation Allison B. Rosen and Lisa Rosenzweig; 33. Medical therapy for male infertility Loren Jones and Craig Niederberger; 34. Management of the varicocele in the treated patient Michael L. Eisenberg and Larry I. Lipshultz; 35. Sperm extraction in the treated patient Wayland Hsiao and Peter N. Schlegel; 36. Post-mortem sperm extraction Andrew C. Kramer and Ellen R. Goldmark; 37. Fertility following antineoplastic therapy in the male: intrauterine insemination and the assisted reproductive technologies Hey-Joo Kang, Jack Huang and Owen K. Davis; Index.

John P. Mulhall is Director of the Male Sexual and Reproductive Medicine Program, Urology Service, Department of Surgery, Memorial Sloan–Kettering Cancer Center, New York, NY, USA.