Hormone therapy and the brain, a clinical perspective on the role of estrogen.

Written by an acknowledged leader in the field, this is a vital clinical reference on the influence of estrogen replacement therapy on Alzheimer's disease, visual dementia, stroke, disorders of movement, epilepsy, migraine headache, and multiple sclerosis. It opens with introductory information and an overview of estrogen and the brain and with coverage of the mechanisms of estrogen action on the brain and the neuroprotective effects of estrogen. Two sections cover the effects of estrogen replacement therapy on mood behavior and cognition and a major section focuses on Alzheimer's disease and other dementias. Another key section covers other neurological disorders, including stroke prevention after menopause, stroke protection in men, neuroprotection after stroke, movement disorders, epilepsy, migraine headache, and multiple sclerosis. Includes color illustrations, bibliographic references and index.

Overview. Estrogen and the brain: Estrogen production and metabolism. Brain as an estrogen target organ. Mechanisms of estrogen action on the brain. Receptor-mediated effects. Receptor types. Selective estrogen receptor modulators and transcriptional control. Effects not mediated by intranuclear receptors. Dietary estrogens. Mood. Cognition: Animal studies. Human studies Estrogen therapy and cognition: observational studies. Estrogen therapy and cognition: randomized controlled trials. Dementia: Alzheimer's disease. Estrogen and Alzheimer's disease: possible mechanisms, Estrogen therapy and risk of Alzheimer's disease. Estrogen replacement and Alzheimer's risk: strength of association, estrogen therapy and cognitive deficits of Alzheimer's disease, indirect markers of estrogen exposure. Vascular dementia. Cerebrovascular disease: Prevention of stroke, stroke prevention after the menopause, stroke prevention in men. Neuroprotection after stroke. Other neurological disorders: Movement disorders. Epilepsy. Migraine headache. Multiple sclerosis. Future directions. Index.