Image-Guided Radiotherapy of Lung Cancer

Lung cancer is the leading cause of cancer death in the United States, but IGRT (image guided radiation therapy) offers the possibility of more aggressive and enhanced treatments. The only available source on the subject that emphasizes new imaging techniques, and provides step-by-step treatment guidelines for lung cancer, this source helps clinicians locate and target tumors with enhanced speed, improve the accuracy of radiation delivery, and correctly target cancerous masses while avoiding surrounding structures.

Edited by radiation oncology experts from the renowned M.D. Anderson Cancer Center, this guide:

• focuses on novel approaches using IGRT, particularly PET/CT, SPECT, 4-D CT, stereotactic body radiation therapy, IMRT and proton radiotherapy, and offers expert guidance on the dose, fractionation, target volume delineation (including recommended margins with and without respiratory gating based on our new 4-D CT study), and normal tissue tolerances
• stands as the first step-by-step guide for radiation oncologists to implement new image-guided techniques into their day-to-day clinical practice, and considers the practical issues of implementing these approaches into their routine
• helps clinicians use imaging technologies to detect changes in tumor size, shape, position, or metabolism over a course of radiotherapy treatment
• provides disease stage-specific treatment guidelines and clearly lays out imaging techniques
• serves as roadmap for future research and development

Radiotherapy Guidelines and Techniques for Nsclc. Introduction. Stage Based Radiotherapy Guidelines. Radiotherapy Guidelines in Small Cell Lung Cancer. Introduction. Stages Based Radiotherapy Guidelines. Image-Guided Staging, Treatment Planning and Clinical Outcome Prediction/ Evaluation Using PET/CT, SPECT. Imaging Based Lung Cancer Staging. Where to Target and Where to Spare: Incorporation of Pet/Ct and SPECT Imaging Into Treatment Planning. Who Will Recur and Who Will Suffer From Complication: Evaluation and Prediction Based On Imagines. Tumor Motion Consideration: 4-D Ct Based Radiotherapy Planning and Delivery. How Much Lung Cancer Moves Based On 4-D Ct Study. What Is Individualized Optimal Treatment Planning and Delivery, What Is The Optimal Margins. On-Board Imaging Evaluation. Implanted Fiducials and Respiratory Gated Radiotherapy. Indication and Limitation. Reduced Margin Using Implanted Fiducials and On-Board Imaging. Stereotactic Body Radiation Therapy (Sbrt) In Stage I, Selective Stage Ii and Isolated Peripheral Recurrent Nsclc. Radiobiology. Indications and Contra-Indications. Dose and Fractionation Regiments. Image-Guided Sbrt Planning and Delivery. Normal Tissue Tolerance. Clinical Outcome: Local Control, Survival and Toxicity. IMRT In Selective Locally Advanced Nsclc. Indications and Contraindications. Optimizing IMRT Planning In Lung Cancer, IMRT Quality Control. Clinical Outcome. Image-Guided Proton Radiotherapy. What Is Proton Beam. Image-Guided Proton Beam Treatment Planning. Image-Guided Dose Escalation/Acceleration Of Proton Radiotherapy In Stage I Nsclc. Image-Guided Concurrent Chemotherapy and Dose Escalated Proton Therapy In Stage Iii Nsclc. Pre-Clinical and Clinical Outcome. Future Development: Deformable Registration to Track Tumor Motion and 4-D Radiotherapy Planning and Verification. What Is Deformable Registration, How To Track Tumor Motion. 4-D Radiotherapy Planning Based On Tumor Motion. Future Development of 4-D Delivery. Future Development: 4-D Ct Based Lung Ventilation Study: Potential Role In Radiotherapy Planning.