Molecular Mechanisms of Angiogenesis
From Ontogenesis to Oncogenesis


Language: Anglais
Cover of the book Molecular Mechanisms of Angiogenesis

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Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells…) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels.

This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization.

Emergence of Endothelial Cells During Vascular Development

Eichmann, Anne (et al.)

Pages 3-23

Lymphatic Vascular Morphogenesis

Tatin, Florence (et al.)

Pages 25-44

Finding New Partnerships: The Function of Individual Extracellular Receptor Domains in Angiogenic Signalling by VEGF Receptors

Hyde, Caroline A. C. (et al.)

Pages 47-75

Wnt/Frizzled Signaling in the Vasculature

Couffinhal, Thierry (et al.)

Pages 77-97

BMP9, BMP10, and ALK1: An Emerging Vascular Signaling Pathway with Therapeutic Applications

Bailly, Sabine

Pages 99-119

Apelin Signaling in Retinal Angiogenesis

Audigier, Yves (et al.)

Pages 121-148

Emerging Role of the Two Related Basic Helix-Loop-Helix Proteins TAL1 and LYL1 in Angiogenesis

Pinet, Valérie (et al.)

Pages 149-167

Hypoxia and Extracellular Matrix Remodeling

Muller, Laurent (et al.)

Pages 171-197

Sphingosine-1-Phosphate in Hypoxic Signaling

Cuvillier, Olivier

Pages 199-217

Reciprocal Crosstalk Between Angiogenesis and Metabolism

Laurent, Gaëlle (et al.)

Pages 219-233

Endothelial Progenitor Cells and Cardiovascular Ischemic Diseases: Characterization, Functions, and Potential Clinical Applications

Smadja, David M. (et al.)

Pages 235-264

Endothelial Cell Reactions to Oxygen: Implications for Cancer

Oliveira, Rodrigo Leite (et al.)

Pages 267-282

Tumor Angiogenesis and Lymphangiogenesis: Microenvironmental Soil for Tumor Progression and Metastatic Dissemination

Paupert, Jenny (et al.)

Pages 283-306

Angiogenesis and Invasion in Malignant Glioma: Friends or Foes?

Daubon, Thomas (et al.)

Pages 307-324

Role of Endothelial Cells in Tumor Escape from Immunity

Soncin, Fabrice

Pages 325-337

Tumor High Endothelial Venules and Lymphocyte Trafficking

Veerman, Krystle M. (et al.)

Pages 339-352

Posttranscriptional Regulation of Angiogenesis Through AU-Rich mRNA Degradation: Potential Application in Cancer Therapy

Planel, Séverine (et al.)

Pages 353-372

Antiangiogenic Drugs in Cancer Therapy: Effect on Advanced Renal Cell Carcinoma

Négrier, Sylvie

Pages 375-382

Anti-angiogenic Therapies in Colorectal Cancer

Eveno, Clarisse (et al.)

Pages 383-396

Resistance to Antiangiogenic Treatments via Upregulation of Substitution Pathways

Grépin, Renaud (et al.)

Pages 397-419

VEGF-A Splice Variants: Do They Play a Role in Tumor Responses to Anti-angiogenic Therapies?

Eymin, Beatrice (et al.)

Pages 421-442

Progenitor Endothelial Cells as Biomarkers of Anti-vascular Agents

Taylor, Melissa (et al.)

Pages 445-460

Soluble Vascular Endothelial (VE)-Cadherin: Toward a Marker of Endothelial Dysfunction

Sidibé, Adama (et al.)

Pages 461-478

The Prognostic and Predictive Value of VEGF Across Various Tumor Types

Pallaud, Celine

Pages 479-492

• Dr Jean-Jacques Feige, PhD, is President of the French Society of Angiogenesis, research director at INSERM (National Institute for Health and Medical Research) and runs an academic research laboratory (Biology of Cancer and Infection) in Grenoble, France.

• Dr Gilles Pagès, PhD, is deputy President of the French Society of Angiogenesis, research director at INSERM and runs an academic research group at the Institute for Research on Cancer and Aging of Nice (IRCAN) in the Centre Antoine Lacassagne of Nice.

• Dr Fabrice Soncin, PhD, is the former President of the French Society of Angiogenesis, research director at INSERM and runs an academic research team at the CNRS Institute of Biology of Lille, France.
▶ Offers the latest information on the major signaling pathways that control angiogenesis, which is integrated into the description of the cellular events driving developmental, post-natal and pathological angiogenesis

▶ Presents contributions by the leading international experts in the field

▶ Published under the auspices of the French society of angiogenesis<