Paraoxonases in Inflammation, Infection, and Toxicology, 2010
Advances in Experimental Medicine and Biology Series, Vol. 660

The pivotal role of the Paraoxonases (PON) family in a variety of inflammatory diseases, e.g. atherosclerosis, in preventing the toxicity of organophosphorus insecticides and nerve agents and a variety of other compounds has made them an interesting target for both clinicians and scientists alike. Research into the paraoxonase (PON) family of enzymes (PON1, PON2 and PON3) has increased exponentially over the last five years especially following the initiation of paraoxonase conferences.

The objectives of the 3rd ICP remains the same as the previous two conferences: to disseminate the latest aspects of research into the genetics, biochemistry, structural biology, regulation of PONs and their roles in inflammatory diseases e.g. atherosclerosis with expert lectures from 20 invited plenary lecturers and another 30-40 short and poster presentations from young investigators.

The conference organizers anticipate a global attendance at the conference of between 150- 200 persons. Particular aspects of this conference will include the Bert N La Du Memorial Lecture, 3 Memorial Traveling Fellowships for Young Investigators and a round table discussion on the impact of the latest research on PON. UCLA provides a great venue for students, postdoctoral fellows and clinical scientists to interact with experts in the PON fields of study. The explosion of research into the PON family makes this a timely conference to review recent exciting advances in the field and provide an environment for cross-fertilization of ideas, particularly important for researchers new to the field.

ApoE Mimetic Peptide Reduces Plasma Lipid Hydroperoxide Content with a Concomitant Increase in HDL Paraoxonase Activity.- Interrelationships Between Paraoxonase-1 and Monocyte Chemoattractant Protein-1 in the Regulation of Hepatic Inflammation.- Biomarkers of Sensitivity and Exposure in Washington State Pesticide Handlers.- Paraoxonase 1 Status as a Risk Factor for Disease or Exposure.- Engineering Human PON1 in an E. coli Expression System.- The Toxicity of Mixtures of Specific Organophosphate Compounds is Modulated by Paraoxonase 1 Status.- Identification and Characterization of Biomarkers of Organophosphorus Exposures in Humans.- Temporal and Tissue-Specific Patterns of Pon3 Expression in Mouse: In situ Hybridization Analysis.- PON1 and Oxidative Stress in Human Sepsis and an Animal Model of Sepsis.- Paraoxonase 1 Attenuates Human Plaque Atherogenicity: Relevance to the Enzyme Lactonase Activity.- The Role of Paraoxonase 1 in the Detoxification of Homocysteine Thiolactone.- Alteration of PON1 Activity in Adult and Childhood Obesity and Its Relation to Adipokine Levels.- Anti-Inflammatory Properties of Paraoxonase-1 in Atherosclerosis.- Paraoxonase 1 Interactions with HDL, Antioxidants and Macrophages Regulate Atherogenesis – A Protective Role for HDL Phospholipids.- The Effect of HDL Mimetic Peptide 4F on PON1.- The Contribution of High Density Lipoprotein Apolipoproteins and Derivatives to Serum Paraoxonase-1 Activity and Function.- Paraoxonase 1, Quorum Sensing, and P. aeruginosa Infection: A Novel Model.

The first time a connection has been made between Paraoxonases and inflammation, toxicology, and Infection in the same book Includes supplementary material: sn.pub/extras