Redox Chemistry and Interfacial Behavior of Biological Molecules, 1988

The papers in this book were presented at the Third International Symposium on Redox Mechanisms and Interfacial Properties of Molecules of Biological Importance held in Honolulu, Hawaii between October 19-23, 1987. This Symposium was held as part of the 172nd Meeting of The Electrochemical Society which was cosponsored by The Electrochemical Society of Japan with the cooperation of The Japan Society of Applied Physics. The aim of the Symposium was to bring together a group of electrochemists and bio-medical scientists with interests in electrochemistry from around the world to present their most current research results and/or to present up-to-date reviews of current areas of research activity. It is quite clear from the diversity of topics covered in the various papers that electrochemistry and electrochemical techniques and principles have much to contribute to our under­ standing of many important biochemical phenomena. For example, electrochemical studies are providing important insights into the redox properties of biomolecules ranging from relatively small organic molecules such as indoleamine neurotransmitters to very large organic/organometallic molecules which include various redox enzymes or model enzyme systems. Many of the most powerful analytical techniques are now being coupled to electrodes to monitor potential-controlled behaviors of bio­ logical molecules at charged interfaces. Electrochemical techniques are now being developed which permit extraordinarily small electrodes to be inserted into single cells to monitor electroactive biomolecules. Other microelectrodes are being employed to control cell growth and to manipulate single cells.

Supramolecular Effects in the Redox and Coordination Chemistry of Superstruetured Porphyrins.- Electrochemistry of Metalloporphyrins Containing a Metal-Metal or Metal-Carbon Bond.- A Study of the Effects of Ionic Strength and Anion Binding on the Reduction Potential of Cytochrome c Using Microelectrodes.- Electrochemical Reactivity of Strongly Adsorbed Cytochrome c.- Redox Reactivity of Manganese “Capped” Metalloporphyrins.- Metalloporphyrin Films on Solid Electrodes: Reflectance Spectroscopy and AC Impedance Studies in Aqueous and Nonaqueous Media.- Bacterial Cytochrome P-450 Enzymes and Reactions on Immobilized Electrodes. I. Preliminary Studies.- Interfacial Electrochemistry of Promoter-Modified Electrodes for the Rapid Electron-Transfer of Cytochrome c.- SERS Studies on the Electrode Reaction of Cytochrome c at Silver Electrodes in the Presence of Pyridine Derivatives.- The Electrochemical Characterization of Oxene adducts of PFe(ClO4), PFeII, and PFeII(SR) [P = Tetrakis-(2,6-Dichlorophenyl) porphinato Dianion] in Acetonitrile: Models for Compounds I and II of Horseradish Peroxidase and for Activated Cytochrome P-450.- Direct Electrical Communication Between Chemically Modified Enzymes and Metal Electrodes: III. Electron-Transfer Relay Modified Glucose Oxidase and D-Amino Acid Oxidase.- Potential-Controlled Enzymatic Activity of Conducting Enzyme Membrane.- Electro-Enzymatic Studies of the Interfacial Behavior of Proteins.- Catalytic Oxidation of D-Glucose at an Enzyme-Modified Electrode with Entrapped Mediator.- Electrochemistry of the Iron-Molybdenum Cofactor of Nitrogenase: Evidence for Multiple Speciation and Electrocatalytic Behavior.- SERRS as a Probe of Electrode Processes: Interaction of Glucose Oxidase and FAD at Silver Electrodes.- Surface Electrochemistry of Amino Acids: Voltammetry Assisted by EELS, Auger Spectroscopy and LEED.- Electrochemistry and Spectroelectrochemistry of Adenine and Adenosine Complexes with 3d Transition Metals.- Electrochemical Study of the Mechanism and Kinetics of Oxygen Reduction Mediated by Anthracycline Antibiotics Adsorbed on Electrode Surface.- Studies on Redox Phototransformations of Reduced Forms of Coenzyme NADP+ and Related Compounds.- Anticancer Quinones and Quinolines: Mode of Action via Electron Transfer and Oxidative Stress.- Oxidation Pathways of Purine Drugs: Electrochemical, Liquid Chromatographic and Mass Spectrometric Insights.- Electron Transfer Mechanism for Cocaine Action.- Studies of Acid-Base, Hydration-Dehydration and Keto-Enol Equilibria in Aqueous Solutions of a-Ketoacids by Polarography, Linear Sweep Voltammetry and Spectroscopy.- Electron Transfer Oxy-Radical Mechanism for Anticancer Agents: Etoposide, Cu DIPS, and Bis(9-aminoacridines).- Surface Enhanced Raman Scattering (SERS) Spectroscopy of Guanine Derivatives.- Electrochemistry in Cancer: Applications to Pharmacological Studies and Quinone-Containing Antitumor Agents.- On the Electrocatalytic Oxidation of D-Glucose and Related Polyols on Large Pt and Au Electrodes.- Electrochemistry of Some Synthetic Oxygen Carrier Molecules in Water.- Electrochemical Studies on the Generation of Active Oxygen Species in Biological Systems with the Use of Mediators.- Intracellular Voltammetry with Ultrasmall Carbon Ring Electrodes.- Oxidation Chemistry of CNS Indoles.- Organic Electrochemistry IV: Electrochemical Desulfurization Reactions of Thiolumazines.- Determination of Cationic Drugs on a Nafion-Coated Electrode.- Adsorptive Stripping Voltammetric Studies of Biologically-Significant Compounds.- Modified Electrodes Used to Elucidate Electro-chemical Behaviors of Biologically Significant Molecules.- Studies of the Kinetics of Mediated Electrochemical Oxidation at Polymer-Coated Electrodes.- Electrochemical Preparation of Metallophthalocyanine Films.- Selective Determination of Phosphate with PhoE Porin-Lecithin Membrane Electrode.- Membrane Bioenergetics as Viewed from Reconstitution Experiments.- Surface Charge Determines the Aggregation of Hemoglobin Subunits as Predicted by the Surface Free Energy.- Electrocatalysis in Membrane Mimetic Media.- Some Techniques for Investigation of Electrochemical and Ion Transport Properties of Biological Cell Membranes: The Case of Chara Corallina.- Vectorial Control of Cell Growth with Microelectrodes.- Electrochemical Manipulation of Single Cell with a Microelectrode.- of New Alcohol Binding Sites at the Lipid/Water Interface by the Incorporation of Monosialogangliosides into DPPC Liposomes.