Description
Translational Cardiometabolic Genomic Medicine
Coordinator: Rodriguez-Oquendo Annabelle
Language: EnglishSubject for Translational Cardiometabolic Genomic Medicine:
Keywords
Biomarkers; Genome-wide association studies; Mass spectrometry; Metabolic profiling; Metabolome-wide association studies; Metabolomic analysis; Metabolomics; Nuclear magnetic resonance imaging; Systems biology; High-throughput RNA sequencing; Small nuclear RNAs; Small RNAs; Transcriptome; Vault RNAs; Y RNAs; Cardiovascular disease; Co-expression networks; Coronary artery disease; Genetics; Networks; Protein-protein interaction networks; Computational chemistry; DNA; DNA properties; Force field; GWAS; Molecular dynamics; Disease models; Familial hypercholesterolemia; LDL; LDL receptor; Personalized medicine; Stem cell; ABCA1; CAD GWAS; CETP; HDL and CAD; HDL drug development; HDL genetics; HDL GWAS; LCAT; BMI; Body mass index; Common obesity; Fat-mass obesity gene; Letpin; Monogenic obesity; Obesity; Single nucleotide polymorphisms; SNPs; Candidate gene association studies; Candidate genes; Cerebrovascular disease; Familial dementia; Stroke; Vascular cognitive impairment; Vascular dementia; CVD; Epidemiology; Ethnic differences; Health disparities; Risk factors; Cancer; Chemotherapy; Clinical trials; EOC; Treatment; Cholesterol uptake; HDL; Infertility; Metabolism; Age-related macular degeneration; Cholesterol; Complement; Inflammation; Nutrition; Reverse cholesterol transport; Commercial; Intellectual property; Market; Product development; Regulatory
352 p. · 15x22.8 cm · Hardback
Description
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Translational Cardiometabolic Genomic Medicine,edited by Dr. Annabelle Rodriguez-Oquendo, is an important resource to postgraduate (medical, dental and graduate) students, postdoctoral fellows, basic scientists, and physician scientists seeking to understand and expand their knowledge base in the field of genomic medicine as it is applied to cardiometabolic diseases.
This handbook integrates cutting-edge experimental approaches such as chromatin immunoprecipitation paired end tagging (CHIA-PET), to population studies such as the Multi-Ethnic Study of Atherosclerosis.
It encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome to the use of molecular diagnostic testing in predicting increased risk of cardiovascular diseases. Where applicable, this reference also includes chapters related to therapeutic options specifically aligned to molecular targets.
2. Overview of genome wide association studies.
3. Overview of publicly available datasets related to genomic medicine that will become important resources for scientists (such as ENCODE). An emphasis will be placed on how scientists can navigate these sites.
4. Overview of genome editing in animal models and cell lines.
5. Overview of experimental approaches such as CHIA-PET to better understand chromosomal structure and long range chromatin interactions.
6. Overview of transcriptome biology, including microRNA biology and lipid metabolism.
7. Genomic medicine and lipid metabolism: LDL targets.
8. Genomic medicine and lipid metabolism: HDL targets.
9. Genomic medicine and diabetes.
10. Genomic medicine and hypertension.
11. Genomic medicine and vascular dementia (including Alzheimers and stroke).
12. Summary of the translational aspects of the basic science of the human genome and its application to the future of medicine.
- Provides comprehensive research on translational genomic medicine
- Explains state-of-the-art genome editing for stem cells and mouse models with significant relevance to human cardiometabolic disease
- Includes discussions on the functional effects of single nucleotide polymorphisms and cardiometabolic diseases, stratified by sex and race
- Encompasses a range of book chapters that highlight bioinformatic approaches to better understanding functionality of the noncoding regions of the human genome
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