Drug stereochemistry : Analytical methods & pharmacology, , (Drugs & the pharmaceutical sciences series) (3^rd Ed.)

Spanning research from Pasteur's initial separation of the tartaric acid enantiomers to the current marketing and clinical use of stereoisomeric drugs, this Third Edition contains new chapters on molecular chiral recognition, the use of enzymes for the synthesis and resolution of enantiomeric compounds, and the impact of stereochemistry on the ADMET stage of drug discovery, as well as revised and updated sections on chiral liquid and gas phase chromatography, stereoselective biotransformation, and protein binding. Documenting the explosion of advances in the field, this source analyzes transformations in the separation and pharmacological sciences and covers the latest issues regarding intellectual property, patenting, and national and international regulation.

INTRODUCTION. The Early History of Stereochemistry: From the Discovery of Molecular Asymmetry and the First Resolution of a Racemate by Pasteur to the Asymmetrical Chiral Carbon of can't Hoff and Le Bel. Stereochemical Terms and Concepts: An Overview. Molecular Chiral Recognition: An Introduction and Overview. THE SEPARATION AND PREPARATION OF STEREOCHEMICALLY PURE DRUGS. Indriect Methods for the Chromatographic Resolution of Drug Enantiomers: Synthesis and Separation of Diastereomeric Derivatives. The Direct Resolution of Enantiomeric Drugs by Chral Phase Gas Chromatography. HPLC Chiral Stationary Phases for the Stereochemical Resolution of Enantiomeric Compounds: The Current State of the Art. Enzymatic Synthesis and Resolution of Enantiomerically Pure Compounds. PHARMACOKINETIC AND PHARMACODYNAMIC DIFFERENCES BETWEEN DRUG STEREOISOMERS. Stereochemical Considerations in the ADMET Stage of Drug Development. Stereoselective Biotransofrmations: Toxicological Consdquences and Implications. Stereoselective Trasport of Drugs Across Epithelia. Enantioselective Binding of Drugs to Plasma Proteins. Clinical Pharmacokinetics and Pharmacodynamics of Setereoisomeric Drugs. INDUSTRIAL AND REGULATORY PERSPECTIVES ON SINGLE ISOMER DRUGS. Regulatory Perspective of the Development of New Stereoisomeric Drugs. Stereochemicall Pure Drugs Versus Racemates: An Overview. The Development and Marketing of Single Isomer Drugs Versus Racemates: A Legal Perspective.