Description
Oral Bioavailability Assessment
Basics and Strategies for Drug Discovery and Development
Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods Series
Author: El-Kattan Ayman F.
Director of collection: Lee Mike S.
Language: English
Subjects for Oral Bioavailability Assessment:
Keywords
Oral bioavailability; drug permeability; drug solubility; pharmacokinetics; physicochemical and biopharmaceutical parameters; drug metabolism; efflux transporters; uptake transporters; drug discovery and development; Extended Clearance Classification System (ECCS); first pass effect; fa; fg; fh; Biopharmaceutics Drug Disposition Classification System (BDDCS); preclinical and clinical development; in vitro and in vivo ADME assays
448 p. · 15.8x23.9 cm · Hardback
Description
/li>Contents
/li>Biography
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? Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability
? Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development
? Explains how preclinical animal models ? used in preclinical testing ? and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development
? Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)
? Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development
1 Drug Pharmacokinetics and Toxicokinetics 1
2 GIT Anatomy and Physiology and Drug Oral Bioavailability: Impact of Species Differences 35
3 Drug Routes of Excretion 77
4 Physicochemical and Biopharmaceutical Properties that Affect Drug Absorption of Compounds Absorbed by Passive Diffusion 139
5 Physicochemical and Biopharmaceutical Factors Affecting Hepatic/Intestinal First-Pass Effect 173
6 Impact of Intestinal Efflux Transporters on Oral Absorption 203
7 Impact of Influx Transporters on Drug Absorption 269
8 Extended Clearance Classification System (ECCS) and its Utility in Predicting Clearance Rate-Determining Step in Drug Discovery 309
9 In Vitro and In Situ Approaches to Measure Intestinal Permeability and Efflux Transporters 331
10 In Silico Approaches to Predict Intestinal Permeability 347
11 In Vivo Preclinical Approaches to Deconvolute The Contribution of First-Pass Effect from Oral Absorption 357
12 In Vitro Approaches to Assess Hepatic Metabolism and First-Pass Effect 377
13 The Utility of ECCS as a Roadmap to Improve Oral Bioavailability of New Molecular Entities: Industrial Perspective 387
Index 431
AYMAN F. EL-KATTAN, B. Pharm, PhD, is Associate Research Fellow in Pfizer's Pharmacokinetics, Dynamics, and Metabolism Department, Cambridge Laboratories and an Adjunct Professor at College of Pharmacy-University of Rhode Island in Rhode Island, US. Dr. El-Kattan is a reviewer for several journals and is an active member of the American Association of Pharmaceutical Scientists (AAPS). He serves on the executive committee of the Drug Transporter focus group. He has been invited speaker 50 times at national/international conferences and has published over 100 papers in peer-reviewed Journals, book chapters, and proceedings.
