Oil-in-Water Nanosized Emulsions for Drug Delivery and Targeting

• Compiles the step-by-step investigations made concerning the potential of nanosized emulsions on both drug delivery and drug targeting areas by different group of scientists in various laboratories across the world
• Inverts the common nano-emulsions coverage trend of focusing on focused on the particulate system itself, instead exploring the way to turn nanosized emulsions as biomedical tool, as well as, treating the in vitro and in vivo aspects after administration
• Provides an overview of the current state-of-the art regarding the development of tocol emulsions, emulsion adjuvants in immunization research, oxygen-carrying emulsions (called as fluorocarbon emulsion) and emulsions for delivering drugs to nasal and topical (ocular and transdermal) routes

List of Contributors ix

Foreword xi

Preface xiii

1. Introduction: An Overview of Nanosized Emulsions 1

2. Formulation Development of Oil-In-Water Nanosized Emulsions 19

3. Characterization and Safety Assessment F Oil-In-Water Nanosized Emulsions 69

4. Manufacturing and Positioning (Generations) of Oil-In-Water Nanosized Emulsions 169

5. Biofate of Nanosized Emulsions 225

6. Medical or Therapeutical Applications of Oil-In-Water Nanosized Emulsions 259

Part I: Overview of Tocol-Based Emulsions, Oxygen-Carrying Emulsions, Emulsions With Double or Triple Cargos and Emulsion-Like Dispersions 287

7. Overview of Tocol‐Based Emulsions, Oxygen‐Carrying Emulsions, Emulsions With Double or Triple Cargos and Emulsion‐Like Dispersions 289

7.1. Tocol-Based Nanosized Emulsions 291

7.2. Oxygen-Carrying Emulsions 301

7.3. Nanosized Emulsions For Multiple Medicament Loadings, Imaging, and Theranostic Purposes 321

7.4. Emulsion-Like Dispersions 347

Part II: Selected Case Studies 369

8. Selected Case Studies 371

8.1. Case Study 1 - Cationic Nanosized Emulsions: Narration of Commercial Success 373

8.2. Case Study 2 - Fish Oil-Based Nanosized Emulsions 389

Index 423

Tamilvanan Shunmugaperumal, PhD, works at the National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, India. His current research focuses on systematic optimization of formula to prepare various pharmaceutical dosage forms such as solid lipid microparticles, nanosized emulsions, and microspheres, where he seeks to exploit the potential of lipid- and polymer-based drug delivery carriers to eradicate infectious biofilm formation associated with both medical devices and human organs.