Green techniques for organic synthesis and medicinal chemistry

Green chemistry is rapidly becoming a high priority in modern organic synthesis and pharmaceutical R&D, but there is currently no green chemistry book which addresses both organic synthesis and medicinal chemistry. This book presents updated and comprehensive coverage of green chemistry technologies for organic and medicinal chemistry applications. The book is divided into 4 parts: Part I - an introduction to the toxicology of organic chemicals and the concept of green organic synthesis. Part II - covers catalysis, the most important and active topic in green chemistry. Part III - introduces a series of new techniques, including atom economic multicomponent reactions, alternative energy microwave and ultrasound for reactions, solid-phase, fluorous and ionic liquid-based recycling techniques, solvent-free ball milling, and solvent-less microfluidic devices. The green chemistry aspects and limitations (i.e. cost, equipment, expertise) of each technique will be assessed. Part IV – covers applications of green chemistry concepts and special techniques for medicinal chemistry applications including synthesis, analysis, separation, formulation, toxicology, and drug delivery. The book concludes with case studies, illustrating practical applications in the pharmaceutical industry.