Description
Stereoselective Desymmetrization Methods in the Assembly of Complex Natural Molecules, Softcover reprint of the original 1st ed. 2016
Springer Theses Series
Author: Sharpe Robert.J
Language: EnglishSubjects for Stereoselective Desymmetrization Methods in the Assembly...:
Publication date: 06-2018
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Add to cart the print on demand of Sharpe Robert.JPublication date: 06-2016
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Description
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This thesis describes the inception, design, and implementation of stereoselective desymmetrization reactions in the total synthesis of the natural products pactamycin and paspaline. In the case of pactamycin, the author develops a novel asymmetric Mannich reaction and symmetry-breaking reduction strategy to enable facile construction of the complex core architecture in fifteen steps using commercially available materials ? the shortest synthesis to date. He subsequently demonstrates the flexibility of this approach in SAR investigations by highlighting the preparation of twenty-five unique pactamycin structural congeners. For paspaline, the author develops a biocatalytic desymmetrization strategy that allows the highly controlled synthesis of core stereochemistry and provides a platform for the development of new conceptual disconnections in the synthesis of "steroid-like" natural products. This thesis offers a valuable resource for students embarking on a PhD in total synthesis.
Includes detailed figures and schemes in each chapter and subsection to make the thesis easy to follow and understand
Provides extensive and thorough procedural and analytical information to allow the reader to easily replicate experimental conditions described in the thesis
Contains additional information and background not given in currently published literature to give enhanced perspective on the research performed
Includes supplementary material: sn.pub/extras
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