The Wolff-Kishner Reduction and Related Reactions
Discovery and Development


Language: Anglais
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260 p. · 15.2x22.9 cm · Paperback

The Wolff-Kishner reduction was discovered by Russian chemist Nikolai Matveevich Kizhner (1867-1935) in 1911, and reported independently by German chemist Ludwig Wolff (1857-1919) in 1912. The Wolff-Kishner Reduction and Related Reactions: Discovery and Development offers a detailed discussion of this reaction, its discoverers, and its development over the century since its discovery. Derivative name reactions?including the Wharton and Shapiro reactions?are also discussed. The book is generously illustrated with examples from the literature and the corresponding references to the primary literature to aid further reading. It provides a comprehensive review of the century of chemistry that allows the reader to follow the development of this important synthetic reaction. At the same time, this book also provides biographical details about the chemists who discovered and developed the reaction, which adds a human dimension to the discussion. For example, Kizhner discovered this reaction after he had lost both feet to amputation, and at one time he was actually exiled from Siberia. With its unique perspective and comprehensive coverage, this book is essential reading for every organic chemist.

  • Introduces Wolff and Kishner, the discoverers of the reaction, and Huang Ming-Long, the developer of an important modification of the reaction as living persons, rather than just an abstract term used as a form of short-hand to describe the reaction
  • Discusses the discovery of the reaction, and the way that priority for the discovery was settled between Wolff and Kishner
  • Discusses, in depth, the development and usage of the reaction over the century from its discovery to its most recent applications and modifications in synthesis
  • Includes biographical materials about chemists responsible for major derivative name reactions based on the Wolff-Kishner reduction
1. The Discoverers of the Reaction
2. Discovery and Priority
3. The First Two Decades: Mechanism and Early Use in Synthesis
4. To the End of World War II: Expanding the Use of the Reaction
5. After World War II
6. The Modern Wolff-Kishner Reduction
7. Use of the Reaction in Modern Synthesis

Researchers in synthetic organic chemistry in both industry and academia

David E. Lewis is Professor of Chemistry at the University of Wisconsin-Eau Claire. He holds BSc, PhD, and DSc degrees from the University of Adelaide, in South Australia. His research over the last decade has been divided between synthetic organic chemistry and the history of chemistry (specifically, the history of organic chemistry in Russia). He is the author of Advanced Organic Chemistry (Oxford 2016) and of Early Russian Organic Chemists and Their Legacy (Springer Verlag 2012). He has presented seven plenary or invited lectures on the history of organic chemistry in Russia at conferences in Russia (Kazan, Ekaterinburg, and St. Petersburg). He is a member of the Editorial Advisory Board of Minireviews in Organic Chemistry, and of the ad hoc Editorial Advisory Board of The Bulletin for the History of Chemistry.