Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment

Bio-Inspired Strategies for Modeling and Detection in Diabetes Mellitus Treatment focuses on bioinspired techniques such as modeling to generate control algorithms for the treatment of diabetes mellitus. The book addresses the identification of diabetes mellitus using a high-order recurrent neural network trained by an extended Kalman filter. The authors also describe the use of metaheuristic algorithms for the parametric identification of compartmental models of diabetes mellitus widely used in research works such as the Sorensen model and the Dallaman model. In addition, the book addresses the modeling of time series for the prediction of risk scenarios such as hyperglycaemia and hypoglycaemia using deep neural networks. The detection of diabetes mellitus in the early stages or when current diagnostic techniques cannot detect glucose intolerance or prediabetes is proposed, carried out by means of deep neural networks present in the literature. Readers will find leading-edge research in diabetes identification based on discrete high-order neural networks trained with an extended Kalman filter; parametric identification of compartmental models used to describe diabetes mellitus; modeling of data obtained by continuous glucose-monitoring sensors for the prediction of risk scenarios such as hyperglycaemia and hypoglycaemia; and screening for glucose intolerance using glucose-tolerance test data and deep neural networks. Application of the proposed approaches is illustrated via simulation and real-time implementations for modeling, prediction, and classification.

1. Introduction
2. Problem statement
3. Mathematical preliminaries
4. Parameter estimation for glucose-insulin dynamics
5. Neural model for glucose-insulin dynamics
6. Multistep predictor applied to T1DM patients
7. Classification and detection of diabetes mellitus and glucose intolerance
8. Conclusion

Dr. Alma Y. Alanis received her M.Sc. and Ph.D. degrees in electrical engineering from the Advanced Studies and Research Center of the National Polytechnic Institute (CINVESTAV-IPN), Guadalajara, Mexico. Since 2008 she has been with University of Guadalajara, where she is currently a Dean of the Technologies for Cyber-Human Interaction Division, CUCEI. She is also member of the Mexican National Research System (SNI-2) and member of the Mexican Academy of Sciences. She has published papers in recognized International Journals and Conferences, besides eight international books. Dr. Alanis is a Senior Member of the IEEE and Subject Editor of the Journal of Franklin Institute, Section Editor at Open Franklin, Technical Editor at ASME/IEEE Transactions on Mechatronics, and Associate Editor at IEEE Transactions on Cybernetics, Intelligent Automation & Soft Computing and Engeenering Applications of Artifical Intelligence. Moreover, Dr. Alanis is currently serving on a number of IEEE and IFAC Conference Organizing Committees. In 2013 Dr. Alanis received the grant for women in science by L'Oreal-UNESCO-AMC-CONACYT-CONALMEX. In 2015, she received the Marcos Moshinsky Research Award. Her research interest centers on artificial neural networks, learning systems, intelligent control, and intelligent systems.
Dr. Oscar D. Sánchez received his Ph.D. degree in Electronic and Computer Science from the University of Guadalajara. He is a researcher in the Computer Department at the University Center for Exact Sciences and Engineering at the University of Guadalajara. Dr. Sánchez’s research interests are modeling and identification of systems, bioinformatics, optimization and prediction with intelligent systems.
Dr. Alonso Vaca González is a physician at the University of Guadalajara. He holds a Master’s Degree in Medical Microbiology, with diplomas in Applied Public Health, Mental Health, Microbiota, Diagnostic Hematology, Occupational Health and Safety, and Health Business Adm