Bioactive Natural Products (2^nd Ed.)
Detection, Isolation, and Structural Determination, Second Edition

Following the successful format of the original, this new edition presents applications of the most recent techniques for the detection, isolation, and structural determination of bioactive natural products. It features new case studies and illustrations that demonstrate applications of techniques covered in the book. Complementing as much as replacing the first edition, most of the contributors are new. The text includes updates on chemical extraction, and NMR-based structure determination, and new contributions on liquid chromatography linked with mass and NMR spectroscopy, dereplication approaches, assessment of source material for natural products and novel bioassay development.

Introduction and Overview. Detection and Isolation of Bioactive Natural Products. Nuclear Magnetic Resonance Spectroscopy: Strategies for Structure Determination. Quantitative NMR of Bioactive Natural Products. Development and Application of LC-NMR Techniques to the Identification of Bioactive Natural Products. Determination of the Absolute Configuration of Bioactive Natural Products using Exciton Chirality Circular Dichroism. Separation of Enantiomeric Mixtures of Alkaloids and their Biological Evaluation. UV Dereplication of Natural Products Extracts. Liquid Chromatography-Mass Spectrometry in Natural Product Research. Application of High-Speed Counter-Current Chromatography to the Isolation of Bioactive Natural Products. Biosensing Approach in Natural Products Research. Anticancer Drug Discovery and Development from Natural Products. Sourcing Natural Products from Endophytic Microbes. Isolation of Bioactive Natural Products from Myxobacteria. Naturally-occurring Glycosidase Inhibitors. Bioassay-Directed Isolation and Identification of Anti-aflatoxigenic Constituents of Walnuts. Bioactive Peptides in Hen Eggs. Biological Fingerprinting Analysis: Strategy For Screening of Bioactive Compounds in Traditional Chinese Medicines. Antimalarial Compounds from Traditionally-used Medicinal Plants. Germination Stimulant in Smoke:  Isolation and Identification. Plant-associated Toxins: Bioactivity-guided Isolation, Elisa and LCMS Detection.

Professional

Steven M. Colegate, Russell J. Molyneux