Clinical and Translational Science (2nd Ed.)
Principles of Human Research

Coordinators: Robertson David, Williams Gordon H.

Language: Anglais
Cover of the book Clinical and Translational Science

Subject for Clinical and Translational Science

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808 p. · 21.6x27.6 cm · Paperback

Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health.

This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science.

  • Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine
  • Brings insights from international leaders into the discipline of clinical and translational science
  • Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Section I. Fundamental Principles

Chapter 1. Introduction to Clinical Research

Chapter 2. Patient-Oriented Research

Chapter 3. Clinical Trials

Chapter 4. Introduction to Epidemiology

Chapter 5. The Patient-Centered Outcomes Research Institute: Current Approach to Funding Clinical Research and Future Directions

Chapter 6. Health-Care Technology Assessment (HTA)

Chapter 7. Health Services Research: Translating Discovery and Research Into Practice and Policy

Section II. Approaches

Chapter 8. Measurement of Biological Materials

Chapter 9. Imaging Tools in Clinical Research: Focus on Imaging Technologies

Chapter 10. Imaging Tools in Human Research: Focus on Image-Guided Intervention

Chapter 11. Nanotechnology in Clinical and Translational Research

Chapter 12. The Use of Questionnaires and Surveys

Chapter 13. Information Technology

Chapter 14. Principles of Biostatistics

Chapter 15. Good Clinical Practice and Good Laboratory Practice

Section III. Human Genetics

Chapter 16. Introduction to Human Genetics

Chapter 17. Epidemiologic and Population Genetic Studies

Chapter 18. Pharmacogenetics of Drug Metabolism

Chapter 19. Statistical Techniques for Genetic Analysis

Section IV. Human Pharmacology

Chapter 20. Introduction to Clinical Pharmacology

Chapter 21. Adverse Drug Events

Section V. Societal Context of Human Research

Chapter 22. Translating Science to the Bedside: The Innovation Pipeline

Chapter 23. Regulatory Environment

Chapter 24. Ethical Issues in Translational Research and Clinical Investigation

Chapter 25. Clinical Research in the Public Eye

Section VI. Research in Special Populations

Chapter 26. Research in Special Populations: Acute Illnesses; Critical Care; and Surgical Patients

Chapter 27. Research in the Emergency Care Environment

Chapter 28. Psychiatric Disorders

Chapter 29. Research in Special Populations: Geriatrics

Chapter 30. Clinical Research in Neurology

Chapter 31. Research in Pediatrics

Chapter 32. Cancer as a Paradigm for Translational and Clinical Biomedical Research

Chapter 33. Maintaining an Emphasis on Rare Diseases With Research Initiatives and Resources at the National Center for Advancing Translational Sciences

Section VII. Infrastructure

Chapter 34. Clinical and Translational Science Infrastructure

Section VIII. Education, Training and Career Choices

Chapter 35. Education, Training and Career Choices: Training Basic, Clinical, and Translational Investigators

Chapter 36. A Stepwise Approach to a Career in Translational Research

Chapter 37. Physician Careers in the Pharmaceutical Industry

Section IX. Research in Academia

Chapter 38. Industry-Sponsored Clinical Research in Academia

Chapter 39. Governmental Support of Research

Chapter 40. The Role of Nonprofit, Nongovernmental Funding in Support of Biomedical Research

Chapter 41. Modern Drug Discovery and Development

Chapter 42. Pharmaceutical and Biotechnology Sector Support of Research

Section X. Prospectus

Chapter 43. The Future of Clinical Research

Investigators and clinicians involved in biomedical research across multiple fields; post-doctoral fellows and graduate researchers; instructors and trainees in national and international technical clinician and degree programs