Control of Gene Expression by Catecholamines and the Renin-Angiotensin System, Reprinted from MOLECULAR AND CELLULAR BIOCHEMISTRY, 2000 Developments in Molecular and Cellular Biochemistry Series, Vol. 33
Coordonnateurs : Rupp Heinz, Maisch Bernhard
Taking into account that catecholamines and angiotensin II are vital for a balanced gene expression of many cells, the intriguing possibility arises that various disease are initiated or aggravated by such an imbalance. Catecholamine and angiotensin II influences can be in excess arising from, for example, hypercaloric food intake or psychosocial stress. During early progression of heart failure, sympathetic activity and angiotensin II influences also become increased. Due to beta-adrenergic receptor downregulation, depressed catecholamine influences are expected in the final stage of heart failure. An imbalanced influence of catecholamines and angiotensin II on gene expression leads to disordered molecular structures of the cell and an impaired cell function.
This focused issue is organized into chapters concentrating on catecholamines, angiotensin II, and the interaction between catecholamines and angiotensin II. Basic biochemical processes are covered in detail and the potential of these pathways for explaining chronic diseases associated with excess catecholamine and angiotensin II influences should become apparent. It is hoped that this focussed issue triggers novel research into the development of drugs that are targeted at diseases characterized by an imbalanced gene expression involving catecholamines and angiotensin II.
Date de parution : 10-2012
Ouvrage de 239 p.
21x28 cm
Disponible chez l'éditeur (délai d'approvisionnement : 15 jours).
Prix indicatif 158,24 €
Ajouter au panierDate de parution : 11-2000
Ouvrage de 239 p.
21x27.9 cm
Thème de Control of Gene Expression by Catecholamines and the... :
Mots-clés :
Nucleotide; Promoter; biochemistry; gene expression; genes; phosphorylation; protein; receptor; transcription